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Car4em1(cre/ERT2)Jich
Endonuclease-mediated Allele Detail
Summary
Symbol: Car4em1(cre/ERT2)Jich
Name: carbonic anhydrase 4; endonuclease-mediated mutation 1, Jichao Chen
MGI ID: MGI:7522064
Synonyms: Car4CreER
Gene: Car4  Location: Chr11:84848612-84856870 bp, + strand  Genetic Position: Chr11, 51.34 cM
Alliance: Car4em1(cre/ERT2)Jich page
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Car4em1(cre/ERT2)Jich expression driven by 1 gene
 
Mutation details: CRISPR/Cas9 technology was used to replace the start codon of the carbonic anhydrase 4 (Car4) gene with a Cre-ERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain). (J:345362)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Car4 (mouse)
Summary of all recombinase alleles driven by Car4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Car4 Mutation:  25 strains or lines available
References
Original:  J:345362 Hutchison V, et al., Inducible tricolor reporter mouse for parallel imaging of lysosomes, mitochondria, and microtubules. J Cell Biol. 2024 Jan 1;223(1)
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory