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Pmelem1(rtTA,tetO-icre)Osaw
Endonuclease-mediated Allele Detail
Summary
Symbol: Pmelem1(rtTA,tetO-icre)Osaw
Name: premelanosome protein; endonuclease-mediated mutation 1, Masatake Osawa
MGI ID: MGI:7522089
Synonyms: PmelP2A-TetON3G-TRE3G-iCre
Gene: Pmel  Location: Chr10:128540064-128556107 bp, + strand  Genetic Position: Chr10, 77.13 cM
Alliance: Pmelem1(rtTA,tetO-icre)Osaw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:339313
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase, Transactivator)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Pmelem1(rtTA,tetO-icre)Osaw expression driven by 1 gene
 
Mutation details: The P2A-TetON3G-TRE3G-iCre cassette was inserted into the Pmel locus utilizing the CRISPR/Cas9 in an extended pluripotent stem cell (EPSC) line (C57BL/6J background). (J:339313)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pmel (mouse)
Summary of all recombinase alleles driven by Pmel.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pmel Mutation:  38 strains or lines available
Notes
Lentiviral gene trap injected into zygotes.
References
Original:  J:339313 Nasrin M, et al., Generation of Pmel-dependent conditional and inducible Cre-driver mouse line for melanocytic-targeted gene manipulation. Pigment Cell Melanoma Res. 2023 Jan;36(1):53-70
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory