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Fbxo2tm1.1(cre/ERT2)Akg
Targeted Allele Detail
Summary
Symbol: Fbxo2tm1.1(cre/ERT2)Akg
Name: F-box protein 2; targeted mutation 1.1, Andrew K Groves
MGI ID: MGI:7522231
Synonyms: Fbxo2CreERT2
Gene: Fbxo2  Location: Chr4:148245078-148250881 bp, + strand  Genetic Position: Chr4, 78.68 cM
Alliance: Fbxo2tm1.1(cre/ERT2)Akg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:339364
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Fbxo2tm1.1(cre/ERT2)Akg expression driven by 1 gene
 
Mutation details: The targeting vector was designed to insert a Cre/ERT2 fusion protein into the ATG start codon of the F-box protein 2 (Fbxo2) gene. Specifically, this vector includes (from 5' to 3') a cre/ERT2 fusion gene (Cre recombinase fused to a human estrogen receptor ligand binding domain), a polyadenylation signal, and a loxP-flanked neomycin resistance (neo) cassette. The resulting chimeric mice were bred to a Cre transgenic strain to remove the neo cassette. (J:339364)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Fbxo2 (mouse)
Summary of all recombinase alleles driven by Fbxo2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbxo2 Mutation:  20 strains or lines available
References
Original:  J:339364 McGovern MM, et al., Fbxo2(CreERT2): A new model for targeting cells in the neonatal and mature inner ear. Hear Res. 2023 Feb;428:108686
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory