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Gene Expression Data
Assay Details
Assay
Reference: J:198483 Finelli MJ, et al., Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7529726
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-a-casp3
Results
Specimen 3B Control: embryonic day 15.5; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS23: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 3B Control Expression in apoptotic sensory neurons.
Specimen 3B cKO-Nes: embryonic day 15.5; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS23: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 3B cKO-Nes Authors report no impact on neuronal survival.
Specimen S3F DRG Control: embryonic day 12.5; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted S3F DRG Control Expression in apoptotic neurons.
Specimen S3F DRG cKO-Wnt1: embryonic day 12.5; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1tm1.1Abr (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted S3F DRG cKO-Wnt1 No difference in cell death compared to control.
Specimen S6B +/+: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted S6B +/+ Expression in apoptotic neurons.
Specimen S6B L/L: embryonic day 15.5; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Cell Type Level Pattern Image Note
TS23: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted S6B L/L No difference compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory