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Scube2em1(cre/ERT2)Des
Endonuclease-mediated Allele Detail
Summary
Symbol: Scube2em1(cre/ERT2)Des
Name: signal peptide, CUB domain, EGF-like 2; endonuclease-mediated mutation 1, Dean Sheppard
MGI ID: MGI:7530613
Synonyms: Scube2-CreER
Gene: Scube2  Location: Chr7:109397897-109464886 bp, - strand  Genetic Position: Chr7, 57.53 cM
Alliance: Scube2em1(cre/ERT2)Des page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Scube2em1(cre/ERT2)Des expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 technology, a P2A-CreERT2-T2A-GFP-stop codon-rabbit beta globin polyA sequence was inserted into exon 22 of the Scube2 gene. (J:358260)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Scube2 (mouse)
Summary of all recombinase alleles driven by Scube2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scube2 Mutation:  41 strains or lines available
References
Original:  J:358260 Tsukui T, et al., Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis. Nature. 2024 Jul;631(8021):627-634
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory