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Gene Expression Data
Assay Details
Assay
Reference: J:293794 Durbin MD, et al., SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects. Dev Biol. 2020 Aug 15;464(2):124-136
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7531365
Gene symbol: Shroom3
Gene name: shroom family member 3
Reporter: lacZ
Direct Detection
Results
Specimen 1B: embryonic day 9.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS15: fronto-nasal process Present 1B
TS15: mesenchyme derived from lateral plate Present Regionally restricted 1B , 1D Expression is seen in lateral and splanchnic mesoderm just dorsal to the cardiac outflow tract.
TS15: heart Absent 1D , 1B
Specimen 1E: embryonic day 10.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS17: heart atrium Present 1E , 1G
TS17: primitive ventricle Present 1E , 1G
Specimen 1F: embryonic day 12.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS20: heart left ventricle Present 1H , 1F
TS20: heart right ventricle Present 1H , 1F
Specimen not shown: embryonic day 12.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS20: left atrium Present
TS20: right atrium Present
Specimen 1I: embryonic day 10.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS17: aortic sac Present 1I
TS17: outflow tract cardiac muscle Present 1J , 1I
Specimen 1K: embryonic day 10.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS17: atrioventricular endocardial cushion Absent 1K
TS17: primitive ventricle cardiac muscle Strong 1L
TS17: heart septum Present 1L , 1K Expression is seen in the cardiomyocytes within the forming interventricular septum.
Specimen 2A: embryonic day 9.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS15: cardiac neural crest Present 2A
Specimen 2C: embryonic day 10.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS17: secondary heart field Present 2C
Specimen 3A: embryonic day 12.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Cell Type Level Pattern Image Note
TS20: left ventricle cardiac muscle cardiac muscle cell Present 3A
Specimen 3B: embryonic day 12.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Cell Type Level Pattern Image Note
TS20: interventricular septum cardiac muscle cardiac muscle cell Present 3B
Specimen 5D: embryonic day 10.5; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS17: heart Present 5D
Specimen 5E: embryonic day 10.5; Dvl2tm1.2Wds/Dvl2tm1.2Wds, Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS17: heart Present 5E Expression levels are reduced in the mutant.
Specimen S1A: postnatal day 7; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS28: heart left ventricle Present S1A
TS28: heart right ventricle Present S1A
TS28: left atrium Present S1A
TS28: right atrium Present S1A
Specimen S1B: postnatal day 21; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS28: heart left ventricle Present S1B
TS28: heart right ventricle Present S1B
TS28: left atrium Present S1B
TS28: right atrium Present S1B
Specimen S1C: postnatal month 3; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS28: heart left ventricle Present S1C
TS28: heart right ventricle Present S1C
TS28: left atrium Present S1C
TS28: right atrium Present S1C
Specimen S1D: postnatal month 9; Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Structure Level Pattern Image Note
TS28: heart left ventricle Present S1D
TS28: heart right ventricle Present S1D
TS28: left atrium Present S1D
TS28: right atrium Present S1D
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory