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Tg(Flt1-cre/ERT2)1Tmak
Transgene Detail
Summary
Symbol: Tg(Flt1-cre/ERT2)1Tmak
Name: transgene insertion 1, Taija Makinen
MGI ID: MGI:7532647
Synonyms: Flt1-CreERT2, Vegfr1-CreERT2
Transgene: Tg(Flt1-cre/ERT2)1Tmak  Location: unknown  
Alliance: Tg(Flt1-cre/ERT2)1Tmak page
Transgene
origin
Strain of Origin:  C57BL/6NTac
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Flt1-cre/ERT2)1Tmak expression driven by 1 gene
 
Mutation details: A BAC (B6Ng01-247E8) carrying the mouse Flt1 gene was used to generate a transgene by replacing the coding sequence in exon 1 as well as the splice donor site at the junction between exon 1 and intron 1 (50 bp) with a cassette containing the open reading frame for CreERT2 and the Flt1 3' untranslated region. A polyadenylation signal (human growth hormone polyadenylation signal) was inserted 3' of the Flt1 3'UTR sequence. Two independent founder lines were generated, of which one (line 1) showed efficient Cre-mediated recombination and was used for further analyses. (J:341130)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Flt1 (mouse)
Summary of all recombinase alleles driven by Flt1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:341130 Petkova M, et al., Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation. J Exp Med. 2023 Apr 3;220(4)
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory