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Gene Expression Data
Assay Details
Assay
Reference: J:296266 Ogino H, et al., The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex. J Neurosci. 2020 Sep 30;40(40):7625-7636
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7539228
Gene symbol: Pdgfra
Gene name: platelet derived growth factor receptor, alpha polypeptide
Results
Specimen 1D +/+: embryonic day 18.5 (more )
Note: Triple labeled: red - Pdgfra; blue - Olig2 (assay MGI:7539229); green - Vldlr (assay MGI:7539224).
Structure Cell Type Level Pattern Image Note
TS26: neocortex oligodendrocyte precursor cell Present 1D +/+ Merge , 1D +/+ PDGFRa
Specimen 1D -/-: embryonic day 18.5; Vldlrtm1Her/Vldlrtm1Her (more )
Note: Triple labeled: red - Pdgfra; blue - Olig2 (assay MGI:7539229); green - Vldlr (assay MGI:7539224).
Structure Cell Type Level Pattern Image Note
TS26: neocortex oligodendrocyte precursor cell Present 1D -/- PDGFRa , 1D -/- Merge
Specimen 4E Reln+/+: embryonic day 18.5 (more )
Note: Double labeled: red - Pdgfra; green - Mki67 (assay MGI:7539232).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 4E +/+ Primary somatosensory cortex was shown.
Specimen 4E Reln+/-: embryonic day 18.5; Relnrl/Reln+ (more )
Note: Double labeled: red - Pdgfra; green - Mki67 (assay MGI:7539232).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 4E +/- Primary somatosensory cortex was shown. Dramatically increased density (approximately a 50% increase), and the distribution markedly shifted toward the superficial layer. Immunofluorescent signal was also much stronger compared with the control.
Specimen 4J Dab1+/+: embryonic day 18.5 (more )
Note: Double labeled: red - Pdgfra; green - Mki67 (assay MGI:7539232).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 4J left Primary somatosensory cortex was shown.
Specimen 4J Dab1+/yot: embryonic day 18.5; Dab1yot/Dab1+ (more )
Note: Double labeled: red - Pdgfra; green - Mki67 (assay MGI:7539232).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 4J right Primary somatosensory cortex was shown. Dramatically increased density (approximately a 50% increase), and the distribution markedly shifted toward the superficial layer. Immunofluorescent signal was also much stronger compared with the control.
Specimen 5D Vldlr+/+: embryonic day 18.5 (more )
Note: Double labeled: red - Pdgfra; green - Mki67 (assay MGI:7539232).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 5D +/+ Primary somatosensory cortex was shown.
Specimen 5D Vldlr-/-: embryonic day 18.5; Vldlrtm1Her/Vldlrtm1Her (more )
Note: Double labeled: red - Pdgfra; green - Mki67 (assay MGI:7539232).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 5D -/- Primary somatosensory cortex was shown. Increased density by around 50%.
Specimen 6D Adamts3+/+: embryonic day 18.5 (more )
Note: Double labeled: red - Pdgfra; green - Mki67 (assay MGI:7539232).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 6D +/+ Primary somatosensory cortex was shown.
Specimen 6D Adamts3-/-: embryonic day 18.5; Adamts3tm1b(KOMP)Wtsi/Adamts3tm1b(KOMP)Wtsi (more )
Note: Double labeled: red - Pdgfra; green - Mki67 (assay MGI:7539232).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 6D -/- Primary somatosensory cortex was shown. The number of positive cells was significantly decreased compared with the control. Immunofluorescent signal was markedly weaker compared with the control.
Specimen 6I Reln+/+: embryonic day 18.5 (more )
Note: Double labeled: red - Pdgfra; green - Mki67 (assay MGI:7539232).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 6I left Primary somatosensory cortex was shown.
Specimen 6I Reln PA-DV/PA-DV: embryonic day 18.5; Relnem1Mhat/Relnem1Mhat (more )
Note: Double labeled: red - Pdgfra; green - Mki67 (assay MGI:7539232).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 6I right Primary somatosensory cortex was shown. The number of positive cells was significantly decreased compared with the control. Immunofluorescent signal was markedly weaker compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory