Prtn3tm1.1(cre/ERT2,CD4*)Wkas
Targeted Allele Detail
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| Symbol: |
Prtn3tm1.1(cre/ERT2,CD4*)Wkas |
| Name: |
proteinase 3; targeted mutation 1.1, Wolfgang Kastenmuller |
| MGI ID: |
MGI:7539266 |
| Synonyms: |
Prtn3CreERT2-hCD4 |
| Gene: |
Prtn3 Location: Chr10:79715499-79719008 bp, + strand Genetic Position: Chr10, 39.72 cM
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| Alliance: |
Prtn3tm1.1(cre/ERT2,CD4*)Wkas page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:341387
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Inducible, Inserted expressed sequence, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Prtn3tm1.1(cre/ERT2,CD4*)Wkas expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Prtn3 (MGI:893580) |
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Mutation details: An IRES-CreERT2-IRES-humanCD4-FRT-neo-FRT construct was inserted into the 5th exon of the endogenous Prtn3 gene after the endogenous stop codon. The Neomycin cassette used for selection was then removed by the flippase enzyme. The human CD4 coding sequence used in the construct lacks the C-terminal 33 amino acids and contains the F43I mutation, generating a mutated and truncated protein that precludes signaling and association with MHCII.
(J:341387)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Prtn3
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Prtn3 Mutation: |
13 strains or lines available
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| Original: |
J:341387 Ugur M, et al., Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks. Immunity. 2023 Aug 8;56(8):1778-1793.e10 |
| All: |
1 reference(s) |
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Analysis Tools
