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Gene Expression Data
Assay Details
Assay
Reference: J:337132 Hiremath C, et al., Rap1 regulates lumen continuity via Afadin in renal epithelia. Dev Biol. 2023 Jun 3;501:20-27
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7539579
Gene symbol: Pard6b
Gene name: par-6 family cell polarity regulator beta
Antibody: anti-PARD6B (H-64; sc-67392)
Detection system: Secondary antibody
Results
Specimen S1 control: embryonic day 14.5; Rap1atm1Morz/Rap1atm1Morz, Rap1btm1Morz/Rap1btm1Morz (more )
Note: Double labeled: red - Pard6b; green - Ncam1 (assay MGI:7539508).
Structure Level Pattern Image Note
TS22: renal tubule Present S1_control right , S1_control left Expressed in nephron lumens.
TS22: s-shaped body Present S1_control right , S1_control left Expressed in nephron lumens.
Specimen S1 cKO: embryonic day 14.5; Rap1atm1Morz/Rap1atm1Morz, Rap1btm1Morz/Rap1btm1Morz, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Double labeled: red - Pard6b; green - Ncam1 (assay MGI:7539508).
Structure Level Pattern Image Note
TS22: s-shaped body Present S1_cKO right , S1_cKO left Expressed at the apical surface. Defects in lumen formation, with marked discontinuous lumens.
TS22: renal tubule Present S1_cKO right , S1_cKO left
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory