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Tg(Fap-cre)1Rkl
Transgene Detail
Summary
Symbol: Tg(Fap-cre)1Rkl
Name: transgene insertion 1, Raghu Kalluri
MGI ID: MGI:7546824
Synonyms: FAP-Cre
Transgene: Tg(Fap-cre)1Rkl  Location: unknown  
Alliance: Tg(Fap-cre)1Rkl page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Fap-cre)1Rkl expression driven by 1 gene
 
Mutation details: The transgenic construct contains a 5 kb sequence including the Fap (fibroblast activation protein) promoter and part of exon 1 inserted into the pORF-FAP-TK vector to replace the full coding sequence of the Herpes simplex virus thymidine kinase with a cre expression cassette. Founder Line 1 was established. (J:101977, J:325566)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Fap (mouse)
Summary of all recombinase alleles driven by Fap.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:325566 McAndrews KM, et al., Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer. Cancer Discov. 2022 Jun 2;12(6):1580-1597
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory