Cux1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:342123 Sterling NA, et al., P53 independent pathogenic mechanisms contribute to BubR1 microcephaly. Front Cell Dev Biol. 2023;11:1282182
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7548383
Gene symbol:	Cux1
Gene name:	cut-like homeobox 1

Antibody:	anti-CUX1 (11733-1-AP)
Detection system:	Secondary antibody

Results

7F WT ©

Specimen 7F CUX1 WT: postnatal day 21 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cerebral cortex	neuron	Present		7F WT	Expression in late-born neurons.

7F Trp53 cKO ©

Specimen 7F CUX1 Trp53 cKO: postnatal day 21; Emx1^tm1(cre)Krj/Emx1⁺, Trp53^tm1Brn/Trp53^tm1Brn (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: cerebral cortex	Present		7F Trp53 cKO	Expression not altered compared to wild type.

7F BubR1 cKO ©

Specimen 7F CUX1 BubR1 cKO: postnatal day 21; Bub1b^tm1Jvd/Bub1b^tm1Jvd, Emx1^tm1(cre)Krj/Emx1⁺ (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: cerebral cortex	Weak		7F BubR1 cKO	Expression signficantly reduced compared to wild type.

7F dcKO ©

Specimen 7F CUX1 dcKO: postnatal day 21; Bub1b^tm1Jvd/Bub1b^tm1Jvd, Emx1^tm1(cre)Krj/Emx1⁺, Trp53^tm1Brn/Trp53^tm1Brn (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: cerebral cortex	Weak		7F dcKO	Expression minimally improved compared to BubR1 cKO.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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