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Sellem1(cre/ERT2)Mnz
Endonuclease-mediated Allele Detail
Summary
Symbol: Sellem1(cre/ERT2)Mnz
Name: selectin, lymphocyte; endonuclease-mediated mutation 1, Michel C Nussenzweig
MGI ID: MGI:7548487
Synonyms: SellIRES-CreERT2
Gene: Sell  Location: Chr1:163889556-163908354 bp, + strand  Genetic Position: Chr1, 71.37 cM
Alliance: Sellem1(cre/ERT2)Mnz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:342405
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Sellem1(cre/ERT2)Mnz expression driven by 1 gene
    Using CRISPR/Cas9 technology IRES-iCreERT2 cassette was inserted in exon 8 of the Sell gene. (J:342405)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sell (mouse)
Summary of all recombinase alleles driven by Sell.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sell Mutation:  42 strains or lines available
Notes
Lentiviral gene trap injected into zygotes.
References
Original:  J:342405 Merkenschlager J, et al., Continually recruited naive T cells contribute to the follicular helper and regulatory T cell pools in germinal centers. Nat Commun. 2023 Oct 31;14(1):6944
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory