Birc3em1Haka
Endonuclease-mediated Allele Detail
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Symbol: |
Birc3em1Haka |
Name: |
baculoviral IAP repeat-containing 3; endonuclease-mediated mutation 1, Hamid Kashkar |
MGI ID: |
MGI:7560638 |
Synonyms: |
cIAP2 mutant RING, cIap2MutR |
Gene: |
Birc3 Location: Chr9:7848700-7873187 bp, - strand Genetic Position: Chr9, 2.46 cM, cytoband A2
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Alliance: |
Birc3em1Haka page
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Allele Type: |
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Endonuclease-mediated (Not Applicable) |
Mutation: |
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Intragenic deletion
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Mutation details: CRISPR/Cas9 technology generated an 8-bp deletion leading to a frameshift that prolongs the mutant protein by 23 amino acids changing the phenylalanine at position 600 to a leucine (G601QfsTer34). This deletion was generated by simultaneously injecting C57BL/6N zygotes with two sgRNAs targeting Birc2 (5-TCTGCAGGGGGACAATCAAG-3) and Birc3 (5-ATCTGTAGAGGGACCATCAA-3) and was generated at the same time as the Birc2em1Haka allele.
(J:342656)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Birc3 Mutation: |
32 strains or lines available
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Original: |
J:342656 Schorn F, et al., cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J. 2023 Nov 15;42(22):e113614 |
All: |
1 reference(s) |
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