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Gt(ROSA)26Sortm1(CD68-cre/ERT2)Drg
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(CD68-cre/ERT2)Drg
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Greaves
MGI ID: MGI:7562289
Synonyms: hCD68-CreERT2
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(CD68-cre/ERT2)Drg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:335680
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(CD68-cre/ERT2)Drg expression driven by 1 gene
 
Mutation details: The targeting vector contains a human CD68 promoter (consisting of CD68 5'; flanking sequence with the 83 bp first intron [IVS-1] of the CD68 gene), a Cre recombinase/ERT2 fusion, an IRES, and polyA sequence. The vector is flanked by PhiC31 attP sites and contains a promoterless neomycin cassette upstream of the CD68 promoter. (J:335680)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cd68 (mouse)
Summary of all recombinase alleles driven by Cd68.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  967 strains or lines available
References
Original:  J:335680 Rumianek AN, et al., A Human CD68 Promoter-Driven Inducible Cre-Recombinase Mouse Line Allows Specific Targeting of Tissue Resident Macrophages. Front Immunol. 2022;13:918636
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory