About   Help   FAQ
Npr3tm1(cre)Hze
Targeted Allele Detail
Summary
Symbol: Npr3tm1(cre)Hze
Name: natriuretic peptide receptor 3; targeted mutation 1, Hongkui Zeng
MGI ID: MGI:7571391
Synonyms: Npr3-IRES2-Cre-neo
Gene: Npr3  Location: Chr15:11839982-11907287 bp, - strand  Genetic Position: Chr15, 5.83 cM
Alliance: Npr3tm1(cre)Hze page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Npr3tm1(cre)Hze expression driven by 1 gene
 
Mutation details: The targeting vector contains, from 5' to 3', a partial Npr3 sequence spanning intron 6 up to and including the endogenous stop codon in exon 8 (also with a frt3 site in intron 7), an internal ribosome entry site 2 sequence (IRES2; allows translation initiation in the middle of an mRNA sequence), a Cre recombinase gene, a bovine growth hormone polyA sequence, an AttB site, a PGK/gb2 promoter-Neomycin resistance gene-PGK polyA cassette, a frt5 site, an mRNA splice acceptor sequence, the 3' portion of the hygromycin gene (Hygro2) with SV40 polyA signal, and an AttP site. (J:260362)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Npr3 (mouse)
Summary of all recombinase alleles driven by Npr3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npr3 Mutation:  49 strains or lines available
References
Original:  J:260362 Daigle TL, et al., A suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality. Cell. 2018 Jul 12;174(2):465-480.e22
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory