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Zic5tm1.1(cre/ERT2)Akg
Targeted Allele Detail
Summary
Symbol: Zic5tm1.1(cre/ERT2)Akg
Name: zinc finger protein of the cerebellum 5; targeted mutation 1.1, Andrew K Groves
MGI ID: MGI:7593739
Synonyms: Zic5-CreER
Gene: Zic5  Location: Chr14:122696572-122703127 bp, - strand  Genetic Position: Chr14, 65.96 cM, cytoband E5
Alliance: Zic5tm1.1(cre/ERT2)Akg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:341534
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Zic5tm1.1(cre/ERT2)Akg expression driven by 1 gene
 
Mutation details: A construct carrying a P2A-GFP-CreER fusion protein, followed by a neomycin resistance cassette flanked by FRT sites was inserted at the start codon of Zic5 in exon 2. Founders were mated with ROSA-FLP mice to remove the neomycin-resistant cassette. (J:341534)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Zic5 (mouse)
Summary of all recombinase alleles driven by Zic5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zic5 Mutation:  37 strains or lines available
References
Original:  J:341534 Thawani A, et al., The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border. Development. 2023 Oct 1;150(19):dev202047
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory