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Dpp4em1(cre/ERT2)Jkpns
Endonuclease-mediated Allele Detail
Summary
Symbol: Dpp4em1(cre/ERT2)Jkpns
Name: dipeptidylpeptidase 4; endonuclease-mediated mutation 1, Jonathan Kipnis
MGI ID: MGI:7595997
Synonyms: Dpp4-creERT2
Gene: Dpp4  Location: Chr2:62160417-62242575 bp, - strand  Genetic Position: Chr2, 35.85 cM, cytoband C2-D
Alliance: Dpp4em1(cre/ERT2)Jkpns page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Dpp4em1(cre/ERT2)Jkpns expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 technology, a cre/ERT2 fusion gene with a P2A self-cleaving peptide were inserted between the 5' UTR and exon 1 of theDpp4 gene. (J:345366)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dpp4 (mouse)
Summary of all recombinase alleles driven by Dpp4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dpp4 Mutation:  73 strains or lines available
References
Original:  J:345366 Smyth LCD, et al., Identification of direct connections between the dura and the brain. Nature. 2024 Feb 7;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory