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Gene Expression Data
Assay Details
Assay
Reference: J:213418 Li D, et al., Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014 Apr 28;29(2):233-40
Assay type: RNA in situ
MGI Accession ID: MGI:7615129
Gene symbol: Sox9
Gene name: SRY (sex determining region Y)-box 9
Probe: Sox9 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1O: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hindlimb digit 1 mesenchyme Present 1O Expressed in skeletal condensations.
TS20: hindlimb digit 2 mesenchyme Present 1O Expressed in skeletal condensations.
TS20: hindlimb digit 3 mesenchyme Present 1O Expressed in skeletal condensations.
TS20: hindlimb digit 4 mesenchyme Present 1O Expressed in skeletal condensations.
TS20: hindlimb digit 5 mesenchyme Present 1O Expressed in skeletal condensations.
TS20: lower leg mesenchyme Present Regionally restricted 1O Expressed in the fibula and tibia condensations.
Specimen 1P: embryonic day 12.5; Irx3tm3.1Hui/Irx3tm3.1Hui, Irx5tm3Hui/Irx5tm3Hui (more )
Structure Level Pattern Image Note
TS20: hindlimb digit 2 mesenchyme Present 1P Similar as in the control. Expressed in skeletal condensations.
TS20: hindlimb digit 3 mesenchyme Present 1P Similar as in the control. Expressed in skeletal condensations.
TS20: hindlimb digit 4 mesenchyme Present 1P Similar as in the control. Expressed in skeletal condensations.
TS20: hindlimb digit 5 mesenchyme Present 1P Similar as in the control. Expressed in skeletal condensations.
TS20: hindlimb digit mesenchyme Present Regionally restricted 1P Expressed in skeletal condensations. Loss of precursors of digit 1 was seen.
TS20: lower leg mesenchyme Present Regionally restricted 1P Expressed in the fibula condensations. Loss of precursors of tibia was seen.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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