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Gene Expression Data
Assay Details
Assay
Reference: J:195264 Vincentz JW, et al., Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest. PLoS Genet. 2013 Mar;9(3):e1003405
Assay type: RNA in situ
MGI Accession ID: MGI:7643422
Gene symbol: Dbh
Gene name: dopamine beta hydroxylase
Probe: Dbh probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2M: embryonic day 11.5 (more )
Structure Cell Type Level Pattern Image Note
TS19: outflow tract endocardial cushion neural crest cell Absent 2M
Specimen 2N: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/0, Twist1tm1Bhr/Twist1tm2Bhr (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: outflow tract endocardial cushion neural crest cell Present Regionally restricted 2N Conditional ablation of Twist1 produces abnormal cellular aggregates. Expression of Dbh was detected in the aggregates.
Specimen 4A: embryonic day 11.5 (more )
Structure Cell Type Level Pattern Image Note
TS19: sympathetic ganglion sympathetic noradrenergic neuron Present 4A , 4A1
TS19: outflow tract endocardial cushion Absent 4A2 , 4A
Specimen 4B: embryonic day 11.5; Hand2tm1Cse/Hand2+, Twist1tm1Bhr/Twist1tm2Bhr, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: sympathetic ganglion sympathetic noradrenergic neuron Present 4B , 4B1
TS19: outflow tract endocardial cushion Strong Regionally restricted 4B , 4B2 Expression was detected in ectopic sympathetic-like neurons.
Specimen 4C: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/0, Hand2tm1Cse/Hand2tm1Dsr, Twist1tm2Bhr/Twist1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: sympathetic ganglion sympathetic noradrenergic neuron Present 4C , 4C1 Reduced expression was observed compared with control.
TS19: outflow tract endocardial cushion Absent 4C2 , 4C
Specimen 4D: embryonic day 11.5; Hand2tm1Cse/Hand2tm1Dsr, Twist1tm1Bhr/Twist1tm2Bhr, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS19: sympathetic ganglion sympathetic noradrenergic neuron Absent 4D , 4D1
TS19: outflow tract endocardial cushion Strong Regionally restricted 4D , 4D2 Expression was detected in ectopic sympathetic-like neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
MGI 6.24 		The Jackson Laboratory