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Gene Expression Data
Assay Details
Assay
Reference: J:345921 Song R, et al., Deletion of the prorenin receptor in the ureteric bud in mice inhibits Dot1/H3K79 pathway. Pediatr Res. 2024 Jan 29;
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7643538
Gene symbol: Dot1l
Gene name: DOT1 like histone lysine methyltransferase
Antibody: anti-Dot1l (ab64077)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2A +/+: embryonic day 17.5; Tg(Hoxb7-cre)5526Cmb/0 (more )
Note: Double labeled: red - Dot1l; green - Aqp2 (assay MGI:7643540).
Structure Cell Type Level Pattern Image Note
TS25: inner medullary collecting duct kidney inner medulla collecting duct intercalated cell Present 1Aa , 1Ac Expression levels are quantified in Fig. 1B.
Specimen 2A UB-/-: embryonic day 17.5; Atp6ap2tm1.1Aich/Atp6ap2tm1.1Aich, Tg(Hoxb7-cre)5526Cmb/0 (more )
Note: Conditional mutant. Double labeled: red - Dot1l; green - Aqp2 (assay MGI:7643540).
Structure Cell Type Level Pattern Image Note
TS25: inner medullary collecting duct kidney inner medulla collecting duct intercalated cell Present 1Ad , 1Ab Expression levels are quantified in Fig. 1B; expression is reduced in the mutant relative to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
MGI 6.24 		The Jackson Laboratory