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Gene Expression Data
Assay Details
Assay
Reference: J:344830 Tsutsumi-Arai C, et al., A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2. J Dent Res. 2024 Jan;103(1):91-100
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7645376
Gene symbol: Pthlh
Gene name: parathyroid hormone-like peptide
Reporter: mCherry
Antibody: anti-mCherry (M11217)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1B: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Pthlh mRNA (assay MGI:7645380).
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted 1B mCherry , 1B Merge Expression is in the superficial layer of the mandibular condylar cartilage.
Specimen 1C: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; yellow - Sox9 (assay MGI:7645386).
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted 1C Expression is in the superficial layer of the mandibular condylar cartilage. In the posterior compartment expressing cells occupied the entire surface of the condylar process but not the gonial process.
TS27: dental sac Present 1C
TS27: temporo-mandibular joint disc Present 1C
TS27: incisor epithelium Present Regionally restricted 1C Expression is in the dental epithelium in the labial cervical loop.
TS27: mandibular fossa Present Regionally restricted 1C Expression is in the fibrous region.
Specimen 1D: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Multi-labeled: red - Pthlh reporter; green - Col10a1 (assay MGI:7645407); blue - Runx2 (assay MGI:7645408); magenta - Sox9 (assay MGI:7645405).
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted 1D , 1d1 Expression is restricted to the superficial layer, occupying 2 to 3 cell layers on the surface.
Specimen 1E: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; blue - Runx2 (assay MGI:7645408).
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted 1E Expression is restricted to the superficial layer, occupying 2 to 3 cell layers on the surface.
Specimen 2B Control PTHrP: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 2B Control PTHrP Expression is in the superficial layer of the mandibular condylar cartilage.
Specimen 2B KO PTHrP: embryonic day 18.5; Pthlhem1Nono/Pthlhem1Nono (more )
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 2B KO PTHrP Expression is in the superficial layer of the mandibular condylar cartilage.
Specimen 2B Control PTH1R: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 2B Control PTH1R Expression is in the superficial layer of the mandibular condylar cartilage.
Specimen 2B KO PTH1R: embryonic day 18.5; Pthlhem1Nono/Pthlhem1Nono (more )
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 2B KO PTH1R Expression is in the superficial layer of the mandibular condylar cartilage.
Specimen 2C Polymorphic: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; yellow - Pthlh protein (assay MGI:7645423).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 2C Polymorphic Expression is in the superficial polymorphic layer and is absent in the hypertrophic chondrocyte layer of the mandibular condylar cartilage.
Specimen 2C Chondrocyte: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; yellow - Pthlh protein (assay MGI:7645423).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 2C Chondrocyte Expression is in the superficial polymorphic layer and is absent in the hypertrophic chondrocyte layer of the mandibular condylar cartilage.
Specimen 3B Control E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh; yellow - Edu.
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 3B E15.5 Control Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3B KO E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh; yellow - Edu.
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 3B E15.5 KO Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3B Control E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh; yellow - Edu.
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 3B E18.5 Control Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3B KO E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh; yellow - Edu.
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 3B E18.5 KO Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3C Control E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlh+ (more )
Note: Triple labeled: red - Pthlh reporter; blue - Runx2 (assay MGI:7645408); yellow - EdU.
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 3C E15.5 Control Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3C KO E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Triple labeled: red - Pthlh reporter; blue - Runx2 (assay MGI:7645408); yellow - EdU.
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 3C E15.5 KO Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3C Control E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Note: Triple labeled: red - Pthlh reporter; blue - Runx2 (assay MGI:7645408); yellow - EdU.
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 3C E18.5 Control Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3C KO E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Triple labeled: red - Pthlh reporter; blue - Runx2 (assay MGI:7645408); yellow - EdU.
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 3C E18.5 KO Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3D Control E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; magenta - Sox9 (assay MGI:7645386).
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 3D E15.5 Control Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3D KO E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh reporter; magenta - Sox9 (assay MGI:7645386).
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 3D E15.5 KO Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3D Control E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; magenta - Sox9 (assay MGI:7645386).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 3D E18.5 Control Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 3D KO E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh reporter; magenta - Sox9 (assay MGI:7645386).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 3D E18.5 KO Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 4A Control E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Col10a1 (assay MGI:7645407).
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 4A E15.5 Control Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 4A KO E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh reporter; green - Col10a1 (assay MGI:7645407).
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 4A E15.5 KO Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 4A Control E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Col10a1 (assay MGI:7645407).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 4A E18.5 Control Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 4A KO E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh reporter; green - Col10a1 (assay MGI:7645407).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 4A E18.5 KO Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 4B Control E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Ihh (assay MGI:7645417).
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 4B E15.5 Control Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 4B KO E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh reporter; green - Ihh (assay MGI:7645417).
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 4B E15.5 KO Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 4B Control E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Ihh (assay MGI:7645417).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 4B E18.5 Control Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 4B KO E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh reporter; green - Ihh (assay MGI:7645417).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 4B E18.5 KO Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 5Aa1 Control E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Runx2 (assay MGI:7645309).
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 5Aa1 Control E15.5 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 5Aa1 KO E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh reporter; green - Runx2 (assay MGI:7645309).
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 5Aa1 KO E15.5 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 5Aa1 Control E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Runx2 (assay MGI:7645309).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 5Aa1 Control E18.5 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 5Aa1 KO E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh reporter; green - Runx2 (assay MGI:7645309).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 5Aa1 KO E18.5 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 5Aa2 Control E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Sp7 (assay MGI:7645312).
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 5Aa2 Control E15.5 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 5Aa2 KO E15.5: embryonic day 15.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh reporter; green - Sp7 (assay MGI:7645312).
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 5Aa2 KO E15.5 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 5Aa2 Control E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Sp7 (assay MGI:7645312).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 5Aa2 Control E18.5 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen 5Aa2 KO E18.5: embryonic day 18.5; Pthlhem1Nono/Pthlhem1Nono (more )
Note: Double labeled: red - Pthlh reporter; green - Sp7 (assay MGI:7645312).
Structure Level Pattern Image Note
TS26: mandible condylar process Present Regionally restricted 5Aa2 KO E18.5 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen S1A P3: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Pthlh mRNA (assay MGI:7645380).
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted S1A merge P3 , S1A mCherry P3 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen S1A P21: postnatal day 21; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Pthlh mRNA (assay MGI:7645380).
Structure Level Pattern Image Note
TS28: mandible condylar process Present Regionally restricted S1A merge P21 , S1A mCherry P21 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen S1C: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh; yellow - Edu.
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted S1C Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen S1D PTHrP: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; yellow - Pthlh protein (assay MGI:7645423).
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted S1D PTHrP Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen S1D PTHrP: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; green - Pth1r (assay MGI:7645422).
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted S1D PTHR1 Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen S1E Polymorphic: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; yellow - Pthlh protein (assay MGI:7645423).
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted S1E Polymorphic layer Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen S1E Chondrocyte: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Double labeled: red - Pthlh reporter; yellow - Pthlh protein (assay MGI:7645423).
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted S1E Chondrocyte layer Expression is in the superficial layers of the mandibular condylar cartilage.
Specimen S1F: postnatal day 3; Pthlhem1Nono/Pthlh+ (more )
Note: Triple labeled: red - Pthlh reporter; green - Pth1r (assay MGI:7645422); magenta - Runx2 (assay MGI:7645408).
Structure Level Pattern Image Note
TS27: mandible condylar process Present Regionally restricted S1F Expression is in the superficial layers of the mandibular condylar cartilage.
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10/22/2024
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