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Gene Expression Data
Assay Details
Assay
Reference: J:132058 Bermingham-McDonogh O, et al., Expression of Prox1 during mouse cochlear development. J Comp Neurol. 2006 May 10;496(2):172-86
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7645520
Gene symbol: Prox1
Gene name: prospero homeobox 1
Results
Specimen 1: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: otocyst Present Regionally restricted 1 Three distinct region of expresssion can be seen.
Specimen 3A: embryonic day 14.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Level Pattern Image Note
TS22: saccule Present 3A
Specimen 3B: embryonic day 14.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Level Pattern Image Note
TS22: utricle Weak 3B Expression in utricle seems to be waning relative to other structures.
Specimen 3C: embryonic day 14.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Level Pattern Image Note
TS22: semicircular canal Present Regionally restricted 3C Experssion in crista of semicircular canal.
Specimen 3D: embryonic day 14.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Cell Type Level Pattern Image Note
TS22: saccule auditory hair cell Present Regionally restricted 3D Co-expression with Myo7a in hair cells.
Specimen 4B: embryonic day 14.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Level Pattern Image Note
TS22: cochlear ganglion Present 4B Expression in spiral ganglion.
TS22: cochlea epithelium Absent 4B No expression in auditory sensory epithelium.
Specimen 4D: embryonic day 14.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Level Pattern Image Note
TS22: cochlea epithelium Absent 4D No expression in auditory sensory epithelium.
Specimen 5B: embryonic day 15.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Level Pattern Image Note
TS23: cochlear ganglion Strong 5B Strong expression in spiral ganglion.
TS23: cochlea epithelium Present Regionally restricted 5B Co expression with Myo7a in subset of cells within zone of proliferating cells (ZNP"C) at basal end.
Specimen 5C: embryonic day 15.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Level Pattern Image Note
TS23: cochlea epithelium Present Regionally restricted 5C Expression in nuclei.
Specimen 5D: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 5D Expression first detected in auditory epitheium at E14.5, in most basal region of organ of Corti. Nuclear expression spanning depth of epithelium.
Specimen 7B: embryonic day 16.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Level Pattern Image Note
TS24: cochlea Present 7B Expression in apical region of cochlear.
TS24: lesser epithelial ridge Present 7B Expression in cells in lesser epithelial ridge (LER).
TS24: cochlear ganglion Present 7B Expression in spiral ganglion.
Specimen 7C: embryonic day 16.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Cell Type Level Pattern Image Note
TS24: cochlea cochlear inner hair cell Absent 7C No expression in Myo7a-expressing inner hair cells.
Specimen 7D: embryonic day 16.0 (more )
Note: Double labeled: green - Prox1; red - Cdkn1b (assay MGI:7645523).
Structure Level Pattern Image Note
TS24: cochlea Present Regionally restricted 7D Expression in only a subset of Cdkn1b-expressing cells.
Specimen 8A: embryonic day 18.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Cell Type Level Pattern Image Note
TS26: cochlea cochlea auditory hair cell Absent 8A No expression in hair cell nuclei.
TS26: cochlea supporting cell of cochlea Present Regionally restricted 8A High level of expression in support cells underlying outer hair cells. No expression in support cells underlying inner hair cells.
Specimen 8B: embryonic day 18.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Cell Type Level Pattern Image Note
TS26: cochlea Deiter's cell Present Regionally restricted 8B Expression in nuclei of Deiters' cells and pillar cells.
TS26: cochlea pillar cell Present Regionally restricted 8B Expression in nuclei of Deiters' cells and pillar cells.
TS26: cochlea inner phalangeal cell Absent 8B
Specimen 8C: embryonic day 18.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Cell Type Level Pattern Image Note
TS26: cochlea Deiter's cell Present Regionally restricted 8C Expression in nuclei of Deiters' cells and pillar cells.
TS26: cochlea pillar cell Present Regionally restricted 8C Expression in nuclei of Deiters' cells and pillar cells.
TS26: cochlea inner phalangeal cell Absent 8C
Specimen 8D: embryonic day 18.0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Cell Type Level Pattern Image Note
TS26: cochlea Deiter's cell Present Regionally restricted 8D Expression in nuclei of Deiters' cells and pillar cells.
TS26: cochlea pillar cell Present Regionally restricted 8D Expression in nuclei of Deiters' cells and pillar cells.
TS26: cochlea inner phalangeal cell Absent 8D
Specimen 9A,B: embryonic day 17.0 (more )
Note: Double labeled: green - Prox1; red - S100a1 (assay MGI:7645524).
Structure Cell Type Level Pattern Image Note
TS25: cochlea pillar cell Present Regionally restricted 9B , 9A Expression in pillar cell nuclei.
Specimen 9D: embryonic day 17.0 (more )
Note: Double labeled: green - Prox1; red - S100a1 (assay MGI:7645524).
Structure Cell Type Level Pattern Image Note
TS25: cochlea Deiter's cell Present Regionally restricted 9D
TS25: cochlea pillar cell Present 9D
TS25: cochlea cochlear inner hair cell Absent 9D
TS25: cochlea inner phalangeal cell Absent 9D
Specimen 10A: postnatal day 0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Cell Type Level Pattern Image Note
TS27: cochlea Deiter's cell Present Regionally restricted 10A
TS27: cochlea pillar cell Present Regionally restricted 10A
TS27: cochlea auditory hair cell Absent 10A
TS27: cochlea border cell of cochlea Absent 10A
TS27: cochlea Hensen cell Absent 10A
TS27: cochlea inner phalangeal cell Absent 10A
TS27: cochlear ganglion Present 10A
Specimen 10B: postnatal day 0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Level Pattern Image Note
TS27: cochlea Present 10B
Specimen 10C: postnatal day 0 (more )
Note: Double labeled: red - Prox1; green - Myo7a (assay MGI:7645521).
Structure Level Pattern Image Note
TS27: cochlea Present 10C
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory