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Gene Expression Data
Assay Details
Assay
Reference: J:79414 Muona A, et al., Developmentally regulated expression of type XV collagen correlates with abnormalities in Col15a1(-/-) mice. Matrix Biol. 2002 Jan;21(1):89-102
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7647124
Gene symbol: Col15a1
Gene name: collagen, type XV, alpha 1
Antibody: anti-type XV collagen
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 2a: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: blood vessel Strong Regionally restricted 2a Expression is in some capillaries of the lower jaw.
TS20: mandibular process Strong Regionally restricted 2a Expression is in some capillaries of the lower jaw.
TS20: Meckel's cartilage Weak 2a

Specimen 2b: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: blood vessel Strong Regionally restricted 2b Expression is in the capillaries of the lower jaw.
TS22: lower jaw Strong Regionally restricted 2b Expression is in the capillaries of the lower jaw.
TS22: Meckel's cartilage Present 2b

Specimen 2c: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: perichondrium Present Regionally restricted 2c Expression is in the perichondrium of the developing digits.

Specimen 3a: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: forebrain pia mater Present 3a
TS21: brain blood vessel Present Regionally restricted 3a Expression is in capillaries of the forebrain region.
TS21: forebrain Present Regionally restricted 3a Expression is in capillaries of the forebrain region.

Specimen 3c: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: 4th ventricle choroid plexus Present Regionally restricted 3c Expression is in the blood vessels of the choroid plexus and is absent in the capillaries of the surrounding hindbrain region.
TS22: brain blood vessel Present Regionally restricted 3c Expression is in the blood vessels of the choroid plexus and is absent in the capillaries of the surrounding hindbrain region.

Specimen 3e: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: spinal cord Absent 3e Absent in blood vessels in the spinal cord.

Specimen 3g: postnatal adult (more )
Structure Level Pattern Image Note
TS28: brain blood vessel Present Regionally restricted 3g Expression is in a subset of blood vessels and to the connective tissue and blood vessels of the pia mater of the cerebral sulci.
TS28: brain pia mater Present Regionally restricted 3g Expression is in a subset of blood vessels and to the connective tissue and blood vessels of the pia mater of the cerebral sulci.

Specimen 3i: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: brain blood vessel Present Regionally restricted 3i Expression is in the blood vessels of the choroid plexus.
TS26: choroid plexus Present Regionally restricted 3i Expression is in the blood vessels of the choroid plexus.
TS26: choroid plexus epithelium Absent 3i

Specimen 4a: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: blood vessel Present Regionally restricted 4a Expression is in blood vessels in the limb.
TS21: limb Present Regionally restricted 4a Expression is in blood vessels in the limb.
TS21: basement membrane Weak Regionally restricted 4a Expression is in the basement membrane of newly formed small, irregular primary myotubes.
TS21: limb muscle Weak Regionally restricted 4a Expression is in the basement membrane of newly formed small, irregular primary myotubes.

Specimen 4b: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: basement membrane Present Regionally restricted 4b Expression is in the basement membrane of each myotube.
TS23: limb muscle Present Regionally restricted 4b Expression is in the basement membrane of each myotube.

Specimen 4c: postnatal adult (more )
Structure Level Pattern Image Note
TS28: basement membrane Present Regionally restricted 4c Expression is in the basement membrane of all muscle fibers.
TS28: limb muscle Present Regionally restricted 4c Expression is in the basement membrane of all muscle fibers.
TS28: capillary Present Regionally restricted 4c Expression is in capillaries in the limb.
TS28: limb Present Regionally restricted 4c Expression is in capillaries in the limb.

Specimen 5a: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: heart blood vessel Present Single cells 5a Expression was restricted to a few capillaries.
TS21: visceral pericardium Present Single cells 5a Expression was restricted to a few capillaries.

Specimen 5c: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: heart blood vessel Present Regionally restricted 5c Expression is in the capillaries of the ventricular wall.
TS22: heart ventricle Present Regionally restricted 5c Expression is in the capillaries of the ventricular wall.
TS22: basement membrane Present Regionally restricted 5c Expression is in the basement membrane of the cardiac muscle.
TS22: cardiac muscle tissue Present Regionally restricted 5c Expression is in the basement membrane of the cardiac muscle.

Specimen 5d: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: heart ventricle wall Present Regionally restricted 5d Expression is in the outer half.

Specimen 5e: postnatal adult (more )
Structure Cell Type Level Pattern Image Note
TS28: cardiac muscle tissue cardiac muscle cell Strong 5e Expression is around the cells.
TS28: capillary Strong Regionally restricted 5e Expression is in the capillaries of the heart.

Specimen 5f: postnatal adult; Col15a1tm1Pih/Col15a1tm1Pih (more )
Structure Level Pattern Image Note
TS28: heart Absent 5f

Specimen 6a: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: blood vessel Strong Regionally restricted 6a Expression is in the capillaries of the developing dorsal root ganglion.
TS21: dorsal root ganglion Present Regionally restricted 6a Expression is along the nerve fibers and in the connective tissue capsule.

Specimen 6b: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: dorsal root ganglion Present Regionally restricted 6b Expression is along the nerve fibers and in the connective tissue capsule.
TS26: blood vessel Present Regionally restricted 6b Expression is in the capillaries of the developing dorsal root ganglion.

Specimen 6c: postnatal adult (more )
Structure Level Pattern Image Note
TS28: basement membrane Present Regionally restricted 6c Expression is in both the endoneurial and perineurial basement membrane zones.
TS28: peripheral nerve Present Regionally restricted 6c Expression is in both the endoneurial and perineurial basement membrane zones.

Specimen 6d: postnatal adult (more )
Note: Double labeled: red - Col15a1; green - alpha- bungarotoxin.
Structure Level Pattern Image Note
TS28: basement membrane Present Regionally restricted 6d Expression is in the skeletal muscle and Schwann cell basement membrane zones, and is absent in the synaptic basement membrane.
TS28: skeletal muscle Present Regionally restricted 6d Expression is in the skeletal muscle and Schwann cell basement membrane zones, and is absent in the synaptic basement membrane.

Specimen 6e: postnatal adult (more )
Note: Double labeled: red - Col15a1; green - alpha- bungarotoxin.
Structure Level Pattern Image Note
TS28: basement membrane Present Regionally restricted 6e Expression is in the skeletal muscle and Schwann cell basement membrane zones, and is absent in the synaptic basement membrane.
TS28: skeletal muscle Present Regionally restricted 6e Expression is in the skeletal muscle and Schwann cell basement membrane zones, and is absent in the synaptic basement membrane.

Specimen 7a: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: perichondrium Present 7a
TS25: cartilage Present Regionally restricted 7a Expression is in the peripheral cartilaginous layers of developing bones.
TS25: bone Absent 7a

Specimen 7c: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: perichondrium Present 7c
TS26: cartilage Present Regionally restricted 7c Expression is in the peripheral cartilaginous layers of developing bones.
TS26: bone Absent 7c

Specimen 7e: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: perichondrium Present 7e
TS27: cartilage Present Regionally restricted 7e Expression is in the peripheral cartilaginous layers of developing bones.
TS27: bone Absent 7e

Specimen 8a: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lung vascular element Present Regionally restricted 8a Expression is in the capillaries and larger blood vessels.
TS21: lung mesenchyme Present Regionally restricted 8a Expression is in the connective tissue septa.
TS21: lobar bronchus mesenchyme Absent 8a Expression is absent in the basement membrane of a large bronchus.

Specimen 8b: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lung vascular element Present 8b
TS22: basement membrane Present Regionally restricted 8b Expression is in the basement membrane of small airways and is absent in the larger airways.
TS22: lung Present Regionally restricted 8b Expression is in the basement membrane of small airways and is absent in the larger airways.

Specimen 8c: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: basement membrane Present Regionally restricted 8c Expression is in the basement membrane of vasculature and respiratory tissue.
TS25: lung Present Regionally restricted 8c Expression is in the basement membrane of vasculature and respiratory tissue.
TS25: lung vascular element Present Regionally restricted 8c Expression is in the basement membrane of vasculature and respiratory tissue.

Specimen 8d: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: lung vascular element Present Regionally restricted 8d Expression is in a few capillaries.

Specimen 9a: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: basement membrane Present Regionally restricted 9a Expression is in the blood vessels of the renal interstitium.
TS27: nephrogenic interstitium Present Regionally restricted 9a Expression is in the blood vessels of the renal interstitium.
TS27: glomerular capillary system of maturing glomerular tuft Present Regionally restricted 9a Expression is in invading vessels destined to generate the capillary loops of the glomerulus.
TS27: Bowman's capsule of maturing renal corpuscle Weak 9a

Specimen 9c: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: basement membrane Present 9c
TS27: glomerular capillary system of maturing glomerular tuft Present 9c
TS27: Bowman's capsule of maturing renal corpuscle Weak 9c

Specimen 9d: postnatal adult (more )
Structure Level Pattern Image Note
TS28: renal tubule basement membrane Present 9d

Specimen not shown E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: brain blood vessel Present Regionally restricted Expression is in a few blood vessels in the fore-, midbrain, and hindbrain regions.
TS17: future spinal cord vascular element Present Regionally restricted Expression is in a few blood vessels in the spinal cord region.

Specimen not shown E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: brain blood vessel Present Regionally restricted Expression is in a few blood vessels in the fore-, midbrain, and hindbrain regions.
TS19: blood vessel Present Regionally restricted Expression is in a few blood vessels in the spinal cord region.
TS19: future spinal cord Present Regionally restricted Expression is in a few blood vessels in the spinal cord region.

Specimen not shown E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: heart ventricle Present Regionally restricted Expression was almost in the whole thickness of the ventricle muscle.

Specimen not shown E18.5: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: heart ventricle Present Regionally restricted Expression was almost in the whole thickness of the ventricle muscle.

Specimen not shown adult: postnatal adult (more )
Structure Level Pattern Image Note
TS28: lung vascular element Weak Regionally restricted


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/17/2024
MGI 6.24
The Jackson Laboratory