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Gene Expression Data
Assay Details
Assay
Reference: J:62806 Gad JM, et al., The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina. Exp Eye Res. 2000 Jun;70(6):711-22
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7647258
Gene symbol: Dcc
Gene name: DCC netrin 1 receptor
Antibody: 2744
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 5A: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: retina nerve fiber layer retinal ganglion cell Strong Regionally restricted 5A , 5B Expression was detected on the retinal ganglion cell axons within the nerve fiber layer.
TS23: retina nuclear layer Mueller cell Present Regionally restricted 5B , 5A Expression was detected in elongated DCC-positive processes extending to the outer limiting membrane of the outer nuclear layer.
TS23: retina nuclear layer Present Regionally restricted 5B , 5A At the outer edge of the outer nuclear layer, cell bodies expressing significant levels of DCC protein were distributed sparsely. Overall, the level of DCC protein detected in the E15.5 outer nuclear layer was low.

Specimen 5C: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: retina nerve fiber layer retinal ganglion cell Strong Regionally restricted 5C , 5D Expression was detected on the retinal ganglion cell axons within the nerve fiber layer.
TS24: neural retina amacrine cell Present 5D , 5C
TS24: retina outer nuclear layer Absent 5C , 5D

Specimen 5E: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: retina ganglion cell layer Strong 5E , 5F
TS26: retina outer nuclear layer Absent 5E , 5F
TS26: retina nerve fiber layer retinal ganglion cell Present Regionally restricted 5E , 5F Expression was detected on the proximal retinal ganglion cell axons that lay within the nerve fiber layer overlying the retinal ganglion cell bodies.

Specimen 6A: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: optic disc retinal ganglion cell Strong 6A Strong expression was detected on the retinal ganglion cell axons within the optic disc.

Specimen 6B: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: optic disc retinal ganglion cell Present Regionally restricted 6B Expression was detected on a subset of the retinal ganglion cell axons within the optic disc at E16.5.

Specimen 6C: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: optic nerve Absent 6C


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/17/2024
MGI 6.24
The Jackson Laboratory