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Phox2bem2(cre/ERT2)Heno
Endonuclease-mediated Allele Detail
Summary
Symbol: Phox2bem2(cre/ERT2)Heno
Name: paired-like homeobox 2b; endonuclease-mediated mutation 1, Hideki Enomoto
MGI ID: MGI:7657397
Synonyms: Phox2bCreERT2
Gene: Phox2b  Location: Chr5:67251751-67256399 bp, - strand  Genetic Position: Chr5, 35.95 cM
Alliance: Phox2bem2(cre/ERT2)Heno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:344865
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Phox2bem2(cre/ERT2)Heno expression driven by 1 gene
 
Mutation details: CRISPR/cas9 mediated recombination using guide RNAs and a donor vector inserted a cre/ERT2-ipA cassette into exon 1 around the first ATG of the gene. (J:344865)
Inheritance:    Not Specified
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Phox2b (mouse)
Summary of all recombinase alleles driven by Phox2b.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phox2b Mutation:  25 strains or lines available
Notes
The allele was generated in ES cells from a ((C57BL/6 x DBA)F1 x C57BL/6N) background
References
Original:  J:344865 Putra BP, et al., Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system. Dev Growth Differ. 2023 Oct;65(8):461-469
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
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