Tafa4<em1.1(cre/ERT2)Ddg> Endonuclease-mediated Allele Detail MGI Mouse (MGI:7709672)

Tafa4^{em1.1(cre/ERT2)Ddg}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Tafa4^{em1.1(cre/ERT2)Ddg}
Name:	TAFA chemokine like family member 4; endonuclease-mediated mutation 1.1, David D Ginty
MGI ID:	MGI:7709672
Synonyms:	Tafa4^CreER, Tafa4^T2a-CreER
Gene:	Tafa4 Location: Chr6:96808164-97037374 bp, - strand Genetic Position: Chr6, 44.8 cM
Alliance:	Tafa4^{em1.1(cre/ERT2)Ddg} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:353123
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:

Endonuclease-mediated (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Tafa4^{em1.1(cre/ERT2)Ddg} expression driven by 1 gene

Mutation details: Using the CRISPR-based homologous recombination technique, the exon 4 of the mouse Tafa4 gene was replaced with T2A-CreER followed by FRT flanked neo selection cassette in 129S6/SvEvTac-derived embryonic stem (ES) cells. The neo-selection cassette was removed by mating to a germline FlpE strain. (J:101977, J:353123)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tafa4 (mouse) Summary of all recombinase alleles driven by Tafa4. Alliance mouse Tafa4 gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Tafa4 Mutation:	11 strains or lines available

References

Original:	J:353123 Zhang D, et al., C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway. bioRxiv. 2024 Jun 11;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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