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Agrpem1(flp)Chua
Endonuclease-mediated Allele Detail
Summary
Symbol: Agrpem1(flp)Chua
Name: agouti related neuropeptide; endonuclease-mediated mutation 1, Streamson C Chua, Jr
MGI ID: MGI:7711960
Synonyms: Agrp-B-Flpe
Gene: Agrp  Location: Chr8:106293327-106306477 bp, - strand  Genetic Position: Chr8, 53.04 cM, cytoband D1-D2
Alliance: Agrpem1(flp)Chua page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Modified isoform(s), Recombinase)
Mutation:    Insertion
 
Agrpem1(flp)Chua expression driven by 1 gene
 
Mutation details: CRISPR/cas9 mediated recombination using guide RNAs targeting exon 1B of the Agrp-B isoform inserted a flpe-polyA cassette disrupting expression of the gene. (J:353317)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Agrp (mouse)
Summary of all recombinase alleles driven by Agrp.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agrp Mutation:  17 strains or lines available
References
Original:  J:353317 Liu SM, et al., The gut signals to AGRP-expressing cells of the pituitary to control glucose homeostasis. J Clin Invest. 2023 Apr 3;133(7)
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory