Fap<em1(cre/ERT2)Nros> Endonuclease-mediated Allele Detail MGI Mouse (MGI:7781802)

Fap^{em1(cre/ERT2)Nros}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Fap^{em1(cre/ERT2)Nros}
Name:	fibroblast activation protein; endonuclease-mediated mutation 1, Nadia Rosenthal
MGI ID:	MGI:7781802
Synonyms:	FAP^creERT2
Gene:	Fap Location: Chr2:62331280-62404365 bp, - strand Genetic Position: Chr2, 35.85 cM
Alliance:	Fap^{em1(cre/ERT2)Nros} page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:

Endonuclease-mediated (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Fap^{em1(cre/ERT2)Nros} expression driven by 1 gene

Mutation details: A Cre-ERT2-bGHpA cassette was introduced to the start codon in exon 1 of the mouse Fap gene using CRISPR/SpCas9 methodologies (gRNAs: AAAAACATCTGGAAAAATGA and AAGGTTAGTGCGTGCCGTCT) in C57BL/6J embryos. (J:101977, J:358406)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fap (mouse) Summary of all recombinase alleles driven by Fap. Alliance mouse Fap gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Fap Mutation:	58 strains or lines available

References

Original:	J:358406 Amrute JM, et al., Targeting immune-fibroblast cell communication in heart failure. Nature. 2024 Nov;635(8038):423-433
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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