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Pmeltm1.1(cre/ERT2)Jkn
Targeted Allele Detail
Summary
Symbol: Pmeltm1.1(cre/ERT2)Jkn
Name: premelanosome protein; targeted mutation 1.1, Ian Jackson
MGI ID: MGI:7783489
Synonyms: Pmel-CMN
Gene: Pmel  Location: Chr10:128540064-128556107 bp, + strand  Genetic Position: Chr10, 77.13 cM
Alliance: Pmeltm1.1(cre/ERT2)Jkn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:358591
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Pmeltm1.1(cre/ERT2)Jkn expression driven by 1 gene
 
Mutation details: A liveimaging cassette that combined Cre/ERT2 (C) with a membrane targeted marcks-mKate2 fluorescent marker (M) and a nuclear localized H2BCerulean marker (N) in a tricistronic construct (CMN), followed by an frt-flanked neomycin selection cassette was inserted into exon 11. The selection cassette was later removed by crossing with FLPe-deleter mice. (J:358591)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pmel (mouse)
Summary of all recombinase alleles driven by Pmel.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pmel Mutation:  38 strains or lines available
References
Original:  J:358591 Wilkinson EL, et al., Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2-mediated recombination in the melanocyte lineage. Pigment Cell Melanoma Res. 2023 Jan;36(1):71-77
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory