Ucn<em1(cre)Good> Endonuclease-mediated Allele Detail MGI Mouse (MGI:7855858)

Ucn^em1(cre)Good
Endonuclease-mediated Allele Detail

Summary

Symbol:	Ucn^em1(cre)Good
Name:	urocortin; endonuclease-mediated mutation 1, Lisa Goodrich
MGI ID:	MGI:7855858
Synonyms:	Ucn^Cre
Gene:	Ucn Location: Chr5:31295407-31296173 bp, - strand Genetic Position: Chr5, 17.11 cM
Alliance:	Ucn^em1(cre)Good page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:

Endonuclease-mediated (Recombinase)

Mutation:

Insertion

Ucn^em1(cre)Good expression driven by 1 gene

Mutation details: CRISPR-Cas9 was used to insert a T2A-cre construct upstream of the endogenous stop codon. Additional mutations include: Ucn NM_001346010: c.312G>T (p.Glu104His); Cre: c.376G>T (p.Val126Phe); Cre: c.1029G>T (p.Gly343Gly). (J:361089)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ucn (mouse) Summary of all recombinase alleles driven by Ucn. Alliance mouse Ucn gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ucn Mutation:	4 strains or lines available

References

Original:	J:361089 Sitko AA, et al., Lateral olivocochlear neurons modulate cochlear responses to noise exposure. Proc Natl Acad Sci U S A. 2025;122(4):e2404558122
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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