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Mrc1em1(cre/ERT2)Jkpns
Endonuclease-mediated Allele Detail
Summary
Symbol: Mrc1em1(cre/ERT2)Jkpns
Name: mannose receptor, C type 1; endonuclease-mediated mutation 1, Jonathan Kipnis
MGI ID: MGI:7859686
Synonyms: Mrc1creERT2
Gene: Mrc1  Location: Chr2:14234225-14336834 bp, + strand  Genetic Position: Chr2, 10.46 cM
Alliance: Mrc1em1(cre/ERT2)Jkpns page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mrc1em1(cre/ERT2)Jkpns expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, a guide RNA (AGAAGCCTCATGGCCCAGAGTGG) was used to introduce a cre/ERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain) fused to a P2A self-cleaving peptide between the 5' UTR and exon 1 of the mannose receptor, C type 1 (Mrc1) gene on chromosome 2. (J:101977, J:361567)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mrc1 (mouse)
Summary of all recombinase alleles driven by Mrc1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mrc1 Mutation:  86 strains or lines available
References
Original:  J:361567 Du S, et al., Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia. bioRxiv. 2024;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory