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Insl3em2(icre/ERT2)Trejj
Endonuclease-mediated Allele Detail
Summary
Symbol: Insl3em2(icre/ERT2)Trejj
Name: insulin-like 3; endonuclease-mediated mutation 2, Jacques J Tremblay
MGI ID: MGI:7865356
Synonyms: Insl3em2(icre)Trejj, Insl3iCre
Gene: Insl3  Location: Chr8:72141896-72143221 bp, + strand  Genetic Position: Chr8, 34.43 cM
Alliance: Insl3em2(icre/ERT2)Trejj page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Insl3em2(icre/ERT2)Trejj expression driven by 1 gene
 
Mutation details: CRISPR/Cas9 genome editing technology was used to insert an iCre coding sequence along with the inducible ERT2 domain into the 5 untranslated region, immediately upstream of the initiation codon. (J:361805)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Insl3 (mouse)
Summary of all recombinase alleles driven by Insl3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Insl3 Mutation:  7 strains or lines available
References
Original:  J:361805 Robert NM, et al., A New Leydig Cell-Exclusive Cre Line Allows Lineage Tracing of Fetal and Adult Leydig Cell Populations in the Mouse. Endocrinology. 2025 Jan 6;166(2)
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory