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Acp2 Gene Detail
Summary
  • Symbol
    Acp2
  • Name
    acid phosphatase 2, lysosomal
  • Synonyms
    Acp-2, LAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:87882
    NCBI Gene: 11432
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91033230-91044443 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.54 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    206 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87882
 protein coding gene Chr2:91033157-91044443 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026145
 protein coding gene Chr2:92511981-92525056 (+)
A/J MGP_AJ_G0026106
 protein coding gene Chr2:88813796-88824998 (+)
AKR/J MGP_AKRJ_G0026087
 protein coding gene Chr2:91268806-91279982 (+)
BALB/cJ MGP_BALBcJ_G0026115
 protein coding gene Chr2:88993525-89004681 (+)
C3H/HeJ MGP_C3HHeJ_G0025866
 protein coding gene Chr2:91545909-91557858 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026566
 protein coding gene Chr2:95778700-95789852 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023956
 protein coding gene Chr2:85323633-85334927 (+)
CAST/EiJ MGP_CASTEiJ_G0025331
 protein coding gene Chr2:92073274-92086343 (+)
CBA/J MGP_CBAJ_G0025844
 protein coding gene Chr2:99025308-99036448 (+)
DBA/2J MGP_DBA2J_G0025980
 protein coding gene Chr2:88414451-88425601 (+)
FVB/NJ MGP_FVBNJ_G0025943
 protein coding gene Chr2:87523206-87535473 (+)
LP/J MGP_LPJ_G0026084
 protein coding gene Chr2:92725168-92738856 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025969
 protein coding gene Chr2:102065450-102077616 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026620
 protein coding gene Chr2:91337584-91350282 (+)
PWK/PhJ MGP_PWKPhJ_G0025066
 protein coding gene Chr2:88142809-88154281 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024867
 protein coding gene Chr2:90908775-90919844 (+)
WSB/EiJ MGP_WSBEiJ_G0025398
 protein coding gene Chr2:91933595-91947531 (+)



Homology
more
  • Human Ortholog
    ACP2, acid phosphatase 2, lysosomal
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACP2, acid phosphatase 2, lysosomal
  • Synonyms
    LAP
  • Links
    NCBI Gene ID: 53
    neXtProt AC: NX_P11117
    UniProt: P11117

  • Chr Location
    11p11.2-p11.11; chr11:47239302-47248906 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene result in skeletal defects and a small percentage of mutant animals exhibit tonic-clonic seizures. Mice with a missense mutation (Gly244Glu) are growth retarded and exhibit a disrupted cerebellum cytoarchitecture, an abnormal hair shaft, and skin malformations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    994
  • Tissues
    186
  • cDNA Data
    91
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002103 Ensembl Gene Model | MGI Sequence Detail 11214 C57BL/6J ±  kb
    transcript ENSMUST00000238832 Ensembl | MGI Sequence Detail 4656 Not Applicable  
    polypeptide ENSMUSP00000159089 Ensembl | MGI Sequence Detail 434 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      Genomic 1
      cDNA 91
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1049, MGD-MRK-1051
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 29
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory