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Chrnb1 Gene Detail
Summary
  • Symbol
    Chrnb1
  • Name
    cholinergic receptor nicotinic beta 1 subunit
  • Synonyms
    Achr-2, AChR beta, Acrb
  • Feature Type
    protein coding gene
  • IDs
    MGI:87890
    NCBI Gene: 11443
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69674862-69686742 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.87 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    274 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87890
 protein coding gene Chr11:69674862-69686769 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018554
 protein coding gene Chr11:70262015-70275788 (-)
A/J MGP_AJ_G0018522
 protein coding gene Chr11:67605010-67616910 (-)
AKR/J MGP_AKRJ_G0018491
 protein coding gene Chr11:69622837-69636194 (-)
BALB/cJ MGP_BALBcJ_G0018494
 protein coding gene Chr11:67930213-67942599 (-)
C3H/HeJ MGP_C3HHeJ_G0018307
 protein coding gene Chr11:69654897-69667964 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018945
 protein coding gene Chr11:72385837-72398031 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016590
 protein coding gene Chr11:64525926-64539033 (-)
CAST/EiJ MGP_CASTEiJ_G0017862
 protein coding gene Chr11:69893800-69905606 (-)
CBA/J MGP_CBAJ_G0018280
 protein coding gene Chr11:75624586-75641542 (-)
DBA/2J MGP_DBA2J_G0018389
 protein coding gene Chr11:67186890-67199198 (-)
FVB/NJ MGP_FVBNJ_G0018379
 protein coding gene Chr11:66828863-66840724 (-)
LP/J MGP_LPJ_G0018459
 protein coding gene Chr11:70824566-70839668 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018402
 protein coding gene Chr11:76234422-76247865 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018987
 protein coding gene Chr11:69886801-69898679 (-)
PWK/PhJ MGP_PWKPhJ_G0017636
 protein coding gene Chr11:67837787-67849847 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017426
 protein coding gene Chr11:69707724-69719617 (-)
WSB/EiJ MGP_WSBEiJ_G0017916
 protein coding gene Chr11:69553654-69565461 (-)



Homology
more
  • Human Ortholog
    CHRNB1, cholinergic receptor nicotinic beta 1 subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNB1, cholinergic receptor nicotinic beta 1 subunit
  • Synonyms
    ACHRB, CHRNB, CMS1D, CMS2A, CMS2C, SCCMS
  • Links
    NCBI Gene ID: 1140
    neXtProt AC: NX_P11230
    UniProt: P11230

  • Chr Location
    17p13.1; chr17:7445061-7457710 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CHRNB1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele lack all tyrosine residues in the beta subunit intracellular loop, display reduced and simplified neuromuscular junctions, and show defective acetylcholine receptor clustering and anchoring at synapses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    60
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    25
  • cDNA Data
    31
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11443 NCBI Gene Model | MGI Sequence Detail 11881 C57BL/6J ±  kb
    transcript NM_009601 RefSeq | MGI Sequence Detail 2128 ZRU/MplStud  
    polypeptide P09690 UniProt | EBI | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005462 acetylcholine receptor subunit beta
      (term hierarchy)
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    • GlyGen
      P09690 1 site
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 5
      cDNA 32
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1037, MGD-MRK-1063
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 10
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:5098 Dickerman RC, et al., Position of the acatalasemia gene in linkage group V of the mouse. J Hered. 1968 May-Jun;59(3):177-8
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory