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Actg1 Gene Detail
Summary
  • Symbol
    Actg1
  • Name
    actin, gamma, cytoplasmic 1
  • Synonyms
    Actl, E51
  • Feature Type
    protein coding gene
  • IDs
    MGI:87906
    NCBI Gene: 11465
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120236513-120239321 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.07 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87906
 protein coding gene Chr11:120236513-120239368 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019494
 protein coding gene Chr11:124793841-124796462 (-)
A/J MGP_AJ_G0019462
 protein coding gene Chr11:119251282-119255419 (-)
AKR/J MGP_AKRJ_G0019432
 protein coding gene Chr11:122836006-122839987 (-)
BALB/cJ MGP_BALBcJ_G0019437
 protein coding gene Chr11:119606045-119607856 (-)
C3H/HeJ MGP_C3HHeJ_G0019243
 protein coding gene Chr11:123174380-123176855 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036210
 protein coding gene ChrX:47492483-47493044 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017511
 protein coding gene Chr11:116243934-116246036 (-)
CAST/EiJ MGP_CASTEiJ_G0018797
 protein coding gene Chr11:124647676-124652377 (-)
CBA/J MGP_CBAJ_G0019214
 protein coding gene Chr11:133608945-133616844 (-)
DBA/2J MGP_DBA2J_G0019326
 protein coding gene Chr11:118621463-118624433 (-)
FVB/NJ MGP_FVBNJ_G0019318
 protein coding gene Chr11:118322454-118324678 (-)
LP/J MGP_LPJ_G0019398
 protein coding gene Chr11:125105123-125107568 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019351
 protein coding gene Chr11:132455007-132456213 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019925
 protein coding gene Chr11:123519554-123524353 (-)
PWK/PhJ MGP_PWKPhJ_G0018563
 protein coding gene Chr11:120048914-120052212 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018355
 protein coding gene Chr11:123287438-123288582 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ACTG1, actin gamma 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACTG1, actin gamma 1
  • Synonyms
    ACT, ACTG, DFNA20, DFNA26, HEL-176
  • Links
    NCBI Gene ID: 71
    neXtProt AC: NX_P63261
    UniProt: P63261

  • Chr Location
    17q25.3; chr17:81509413-81523847 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ACTG1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice in which this gene has been conditionally disrupted in muscle tissue display a reduced mobility and classical hind limb contractures when suspended by the tail. Mice homozygous for a null allele exhibit prenatal lethality, premature death, and progressive hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    888
  • Tissues
    88
  • cDNA Data
    32
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11465 NCBI Gene Model | MGI Sequence Detail 2809 C57BL/6J ±  kb
    transcript NM_001313923 RefSeq | MGI Sequence Detail 1965 C57BL/6  
    polypeptide P63260 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 32
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1090, MGD-MRK-38474, MGI:109429, MGI:2144346
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 22
      Gene Ontology 13
      Phenotypes 19
    • Earliest
      J:31028 Cleveland DW, et al., Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95-105
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory