About   Help   FAQ
Ads2 QTL Detail
Summary
  • Symbol
    Ads2
  • Name
    anti dsDNA antibody 2
  • Synonyms
    Ads-2
  • Feature Type
    QTL
  • IDs
    MGI:87944
    NCBI Gene: 104216
Location &
Maps
less
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome Unknown
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
One of four loci controlling dsDNA level in NZB and NZW strains. Ads1 and Ads2 alleles in NZB are dominant and contribute to high levels of IgM with anti-dsDNA specificity; recessive NZW alleles produce little anti-dsDNA antibody.
Sequences &
Gene Models
less
Other
Accession IDs
less
MGD-MRK-1156, MGD-MRK-1160
References
more
  • Summaries
    All 4
    Phenotypes 1
  • Earliest
    J:7111 Hirose S, et al., Enhancing effect of H-2-linked NZW gene(s) on the autoimmune traits of (NZB X NZW)F1 mice. J Exp Med. 1983 Jul 1;158(1):228-33
  • Latest
    J:7239 Kohno A, et al., Genetic regulation of the class conversion of dsDNA-specific antibodies in (NZB X NZW)F1 hybrid. Immunogenetics. 1983;18(5):513-24
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory