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Agtr1b Gene Detail
Summary
  • Symbol
    Agtr1b
  • Name
    angiotensin II receptor, type 1b
  • Synonyms
    Agtr-1b, Angtr-1b, AT1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:87965
    NCBI Gene: 11608
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:20368637-20421341 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 6.37 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2006 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87965
 protein coding gene Chr3:20368637-20421341 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027103
 protein coding gene Chr3:17555942-17610751 (-)
A/J MGP_AJ_G0027063
 protein coding gene Chr3:17450682-17504959 (-)
AKR/J MGP_AKRJ_G0027032
 protein coding gene Chr3:17650199-17706165 (-)
BALB/cJ MGP_BALBcJ_G0027075
 protein coding gene Chr3:17194079-17250954 (-)
C3H/HeJ MGP_C3HHeJ_G0026816
 protein coding gene Chr3:17654739-17710431 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027520
 protein coding gene Chr3:18648712-18707795 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024882
 protein coding gene Chr3:15500172-15560871 (-)
CAST/EiJ MGP_CASTEiJ_G0026271
 protein coding gene Chr3:17549885-17607092 (-)
CBA/J MGP_CBAJ_G0026794
 protein coding gene Chr3:19074480-19138129 (-)
DBA/2J MGP_DBA2J_G0026928
 protein coding gene Chr3:17058254-17111890 (-)
FVB/NJ MGP_FVBNJ_G0026896
 protein coding gene Chr3:16716579-16769746 (-)
LP/J MGP_LPJ_G0027040
 protein coding gene Chr3:18185625-18243441 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026917
 protein coding gene Chr3:21145305-21200820 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027580
 protein coding gene Chr3:17415300-17472109 (-)
PWK/PhJ MGP_PWKPhJ_G0026004
 protein coding gene Chr3:16769051-16832242 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025813
 protein coding gene Chr3:17208636-17270374 (-)
WSB/EiJ MGP_WSBEiJ_G0026344
 protein coding gene Chr3:17418953-17479203 (-)



Homology
more
  • Human Ortholog
    AGTR1, angiotensin II receptor type 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGTR1, angiotensin II receptor type 1
  • Synonyms
    AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, ATR1, HAT1R
  • Links
    NCBI Gene ID: 185
    neXtProt AC: NX_P30556
    UniProt: P30556

  • Chr Location
    3q24; chr3:148697784-148743008 (+)  GRCh38
Human Diseases
more
  • Diseases
    13 with human AGTR1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from multigenic genotypes
    36 phenotype references
Homozygotes for targeted null mutations are phenotypically normal, but homozygotes for the Agtr1b/Agtr1a double knockout exhibit reductions in growth, survival, blood pressure, and kidney size not found in either single knockout.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    21
  • cDNA Data
    4
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11608 NCBI Gene Model | MGI Sequence Detail 52705 C57BL/6J ±  kb
transcript NM_175086 RefSeq | MGI Sequence Detail 2147 ZRU/MplStud  
polypeptide P29755 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 7
    cDNA 5
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-1194, MGD-MRK-1196, MGD-MRK-1322
References
more
  • Summaries
    All 96
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 13
    Phenotypes 36
  • Earliest
    J:1075 Sasamura H, et al., Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochem Biophys Res Commun. 1992 May 29;185(1):253-9
  • Latest
    J:320691 Yadav VK, et al., Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse. J Clin Invest. 2022 Feb 15;132(4):e153752
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory