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Alas1 Gene Detail
Summary
  • Symbol
    Alas1
  • Name
    aminolevulinic acid synthase 1
  • Synonyms
    5-aminolevulinate synthase, Alas-1, ALAS-N, succinyl-CoA: glycine C-succinyl transferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:87989
    NCBI Gene: 11655
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106110654-106125153 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 57.46 cM, cytoband F1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    404 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87989
 protein coding gene Chr9:106110654-106125853 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035225
 protein coding gene Chr9:108018456-108036366 (-)
A/J MGP_AJ_G0035205
 protein coding gene Chr9:104128844-104143324 (-)
AKR/J MGP_AKRJ_G0035137
 protein coding gene Chr9:106720520-106734946 (-)
BALB/cJ MGP_BALBcJ_G0035198
 protein coding gene Chr9:103811580-103826697 (-)
C3H/HeJ MGP_C3HHeJ_G0034908
 protein coding gene Chr9:107127171-107143051 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035718
 protein coding gene Chr9:110979908-111000189 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032616
 protein coding gene Chr9:101623451-101637487 (-)
CAST/EiJ MGP_CASTEiJ_G0034220
 protein coding gene Chr9:107019310-107037667 (-)
CBA/J MGP_CBAJ_G0034877
 protein coding gene Chr9:114885741-114904067 (-)
DBA/2J MGP_DBA2J_G0035038
 protein coding gene Chr9:103588132-103602544 (-)
FVB/NJ MGP_FVBNJ_G0034986
 protein coding gene Chr9:102359783-102374121 (-)
LP/J MGP_LPJ_G0035114
 protein coding gene Chr9:108246401-108262357 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035025
 protein coding gene Chr9:116539400-116555028 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035740
 protein coding gene Chr9:106962229-106981257 (-)
PWK/PhJ MGP_PWKPhJ_G0033927
 protein coding gene Chr9:103881324-103896111 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033762
 protein coding gene Chr9:107024013-107037801 (-)
WSB/EiJ MGP_WSBEiJ_G0034340
 protein coding gene Chr9:106861095-106876457 (-)



Homology
more
  • Human Ortholog
    ALAS1, 5'-aminolevulinate synthase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALAS1, 5'-aminolevulinate synthase 1
  • Synonyms
    ALAS, ALAS3, ALAS-H, ALASH, MIG4
  • Links
    NCBI Gene ID: 211
    neXtProt AC: NX_P13196
    UniProt: P13196

  • Chr Location
    3p21.2; chr3:52198083-52214327 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    114
  • cDNA Data
    212
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11655 NCBI Gene Model | MGI Sequence Detail 14500 C57BL/6J ±  kb
    transcript NM_001291835 RefSeq | MGI Sequence Detail 3089 C57BL/6  
    polypeptide Q8VC19 UniProt | EBI | MGI Sequence Detail 642 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000003916 5-aminolevulinate synthase, non-specific, mitochondrial
      (term hierarchy)
    • EC
      2.3.1.37
    • InterPro Domains
      IPR015118 5-aminolevulinate synthase presequence
      IPR050087 8-amino-7-oxononanoate synthase class-II
      IPR004839 Aminotransferase, class I/classII
      IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
      IPR010961 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
    Molecular
    Reagents
    less
    • All nucleic 218
      Genomic 4
      cDNA 212
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1268, MGD-MRK-1270
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:10017 Schoenhaut DS, et al., Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites. Nucleic Acids Res. 1989 Sep 12;17(17):7013-28
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory