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Amd1 Gene Detail
Summary
  • Symbol
    Amd1
  • Name
    S-adenosylmethionine decarboxylase 1
  • Synonyms
    AdoMetDC, Amd-1, SAMDC
  • Feature Type
    protein coding gene
  • IDs
    MGI:88004
    NCBI Gene: 11702
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:40163454-40178184 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 21.85 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88004
 protein coding gene Chr10:40163454-40178184 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017162
 protein coding gene Chr10:38838385-38854933 (-)
A/J MGP_AJ_G0017139
 protein coding gene Chr10:37796069-37808640 (-)
AKR/J MGP_AKRJ_G0017099
 protein coding gene Chr10:38338737-38351202 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0016922
 protein coding gene Chr10:38658442-38672537 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017560
 protein coding gene Chr10:40048971-40069505 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015256
 protein coding gene Chr10:35771383-35782255 (-)
CAST/EiJ MGP_CASTEiJ_G0016501
 protein coding gene Chr10:38842894-38858993 (-)
CBA/J MGP_CBAJ_G0016896
 protein coding gene Chr10:41879059-41895145 (-)
DBA/2J MGP_DBA2J_G0017001
 protein coding gene Chr10:37314546-37328116 (-)
FVB/NJ MGP_FVBNJ_G0016996
 protein coding gene Chr10:36814967-36865196 (-)
LP/J MGP_LPJ_G0017078
 protein coding gene Chr10:38830388-38842093 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017026
 protein coding gene Chr10:42721163-42732856 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017597
 protein coding gene Chr10:38315494-38329076 (-)
PWK/PhJ MGP_PWKPhJ_G0016281
 protein coding gene Chr10:37187449-37199886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016065
 protein coding gene Chr10:38145402-38160888 (-)
WSB/EiJ MGP_WSBEiJ_G0016564
 protein coding gene Chr10:38617913-38637919 (-)



Homology
more
  • Human Ortholog
    AMD1, adenosylmethionine decarboxylase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMD1, adenosylmethionine decarboxylase 1
  • Synonyms
    ADOMETDC, AMD, SAMDC
  • Links
    NCBI Gene ID: 262
    neXtProt AC: NX_P17707
    UniProt: P17707

  • Chr Location
    6q21; chr6:110814617-110898879 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AMD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality before somite formation and embryonic growth arrest.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    970
  • Tissues
    120
  • cDNA Data
    162
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11702 NCBI Gene Model | MGI Sequence Detail 14731 C57BL/6J ±  kb
transcript NM_009665 RefSeq | MGI Sequence Detail 3206 ZRU/MplStud  
polypeptide P0DMN7 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 166
    Genomic 2
    cDNA 163
    Primer pair 1

    Microarray probesets 10
Other
Accession IDs
less
MGD-MRK-1293, MGD-MRK-1294
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory