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Anxa7 Gene Detail
Summary
  • Symbol
    Anxa7
  • Name
    annexin A7
  • Synonyms
    Anx7, synexin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88031
    NCBI Gene: 11750
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20505344-20530009 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    651 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88031
 protein coding gene Chr14:20505328-20530201 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021036
 protein coding gene Chr14:13214534-13240809 (-)
A/J MGP_AJ_G0020985
 protein coding gene Chr14:12909178-12933675 (-)
AKR/J MGP_AKRJ_G0020962
 protein coding gene Chr14:13431293-13455668 (-)
BALB/cJ MGP_BALBcJ_G0020988
 protein coding gene Chr14:13012806-13037182 (-)
C3H/HeJ MGP_C3HHeJ_G0020772
 protein coding gene Chr14:13369144-13394421 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021421
 protein coding gene Chr14:13709932-13735320 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018989
 protein coding gene Chr14:13216703-13243681 (-)
CAST/EiJ MGP_CASTEiJ_G0020296
 protein coding gene Chr14:13127498-13155172 (-)
CBA/J MGP_CBAJ_G0020738
 protein coding gene Chr14:14398489-14435559 (-)
DBA/2J MGP_DBA2J_G0020861
 protein coding gene Chr14:12734641-12759500 (-)
FVB/NJ MGP_FVBNJ_G0020844
 protein coding gene Chr14:12629022-12653593 (-)
LP/J MGP_LPJ_G0020937
 protein coding gene Chr14:13436338-13462451 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020870
 protein coding gene Chr14:14180171-14205833 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021454
 protein coding gene Chr14:13220051-13245818 (-)
PWK/PhJ MGP_PWKPhJ_G0020045
 protein coding gene Chr14:12296827-12321496 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019867
 protein coding gene Chr14:12999212-13026438 (-)
WSB/EiJ MGP_WSBEiJ_G0020352
 protein coding gene Chr14:13199564-13224975 (-)



Homology
more
  • Human Ortholog
    ANXA7, annexin A7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANXA7, annexin A7
  • Synonyms
    ANX7, SNX, SYNEXIN
  • Links
    NCBI Gene ID: 310
    neXtProt AC: NX_P20073
    UniProt: P20073

  • Chr Location
    10q22.2; chr10:73375101-73414076 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 3 genetic backgrounds
    3 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele are viable but exhibit altered Ca2+ signaling and/or homeostasis in cardiomyocytes and glia cells, and changes in erythrocyte shape, osmotic resistance, platelet number and aggregation velocity. Homozygotes for another null allele die at ~E10 with cerebral hemorrhage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    28
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11750 NCBI Gene Model | MGI Sequence Detail 24666 C57BL/6J ±  kb
    transcript NM_001374757 RefSeq | MGI Sequence Detail 2824 ZRU/MplStud  
    polypeptide Q07076 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 6
      cDNA 32
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1336, MGI:2145610, MGI:2145612
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 1
      Gene Ontology 15
      Phenotypes 17
    • Earliest
      J:19395 Magendzo K, et al., Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain. J Biol Chem. 1991 Feb 15;266(5):3228-32
    • Latest
      J:345189 Gilhooley MJ, et al., ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration. Exp Eye Res. 2021 Jun;207:108553
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory