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Apoe Gene Detail
Summary
  • Symbol
    Apoe
  • Name
    apolipoprotein E
  • Feature Type
    protein coding gene
  • IDs
    MGI:88057
    NCBI Gene: 11816
  • Alliance
    gene page
  • Transcription Start Sites
    48 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19430034-19433113 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.94 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88057
 protein coding gene Chr7:19430034-19434326 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031792
 protein coding gene Chr7:17735963-17739021 (-)
A/J MGP_AJ_G0031768
 protein coding gene Chr7:17345795-17348850 (-)
AKR/J MGP_AKRJ_G0031694
 protein coding gene Chr7:17827523-17830566 (-)
BALB/cJ MGP_BALBcJ_G0031773
 protein coding gene Chr7:17551365-17554422 (-)
C3H/HeJ MGP_C3HHeJ_G0031495
 protein coding gene Chr7:18091914-18094972 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032239
 protein coding gene Chr7:18610015-18613072 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029305
 protein coding gene Chr7:18995199-18998213 (-)
CAST/EiJ MGP_CASTEiJ_G0030838
 protein coding gene Chr7:14528226-14531266 (-)
CBA/J MGP_CBAJ_G0031457
 protein coding gene Chr7:19287864-19290922 (-)
DBA/2J MGP_DBA2J_G0031612
 protein coding gene Chr7:17299626-17302669 (-)
FVB/NJ MGP_FVBNJ_G0031564
 protein coding gene Chr7:17168081-17171124 (-)
LP/J MGP_LPJ_G0031695
 protein coding gene Chr7:18047515-18050573 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031600
 protein coding gene Chr7:19108568-19111626 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032267
 protein coding gene Chr7:17440673-17443716 (-)
PWK/PhJ MGP_PWKPhJ_G0030562
 protein coding gene Chr7:14399606-14402662 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030389
 protein coding gene Chr7:12147547-12150593 (-)
WSB/EiJ MGP_WSBEiJ_G0030938
 protein coding gene Chr7:17657353-17660396 (-)



Homology
more
  • Human Ortholog
    APOE, apolipoprotein E
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOE, apolipoprotein E
  • Synonyms
    AD2, APO-E, ApoE4, LDLCQ5, LPG
  • Links
    NCBI Gene ID: 348
    neXtProt AC: NX_P02649
    UniProt: P02649

  • Chr Location
    19q13.32; chr19:44905791-44909393 (+)  GRCh38
Human Diseases
more
  • Diseases
    40 with human APOE associations

Human Disease Mouse Models
      
IDs
IDs
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IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    13 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    171 phenotypes from 11 alleles in 26 genetic backgrounds
    307 phenotypes from multigenic genotypes
    19 images
    2677 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations at this locus cause diet-induced hypercholesterolemia and atherosclerosis. Homozygous null mutants also develop foam-cell rich deposits in proximal aorta, impaired blood-nerve and blood-brain barriers, and many xanthomatous lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    283
  • GO References
    42
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1052
  • Tissues
    189
  • cDNA Data
    1790
  • Literature Summary
    47
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002985 Ensembl Gene Model | MGI Sequence Detail 3080 C57BL/6J ±  kb
    transcript ENSMUST00000174064 Ensembl | MGI Sequence Detail 1408 Not Applicable  
    polypeptide ENSMUSP00000133302 Ensembl | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1806
      Genomic 2
      cDNA 1790
      Primer pair 6
      Other 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1376, MGI:2141887
    References
    more
    • Summaries
      All 3207
      Developmental Gene Expression 47
      Diseases 13
      Gene Ontology 42
      Phenotypes 2677
    • Earliest
      J:5183 Forsthoefel PF, et al., Linkage relationships of Strong's luxoid gene in the mouse. J Hered. 1970 Mar-Apr;61(2):64-6
    • Latest
      J:355486 Marino C, et al., APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation. Alzheimers Dement. 2024 Feb;20(2):819-836
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory