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Araf Gene Detail
Summary
  • Symbol
    Araf
  • Name
    Araf proto-oncogene, serine/threonine kinase
  • Synonyms
    1200013E08Rik, A-Raf, Araf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88065
    NCBI Gene: 11836
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:20664053-20726758 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 16.30 cM, cytoband A2-A3.1
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1462 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88065
 protein coding gene ChrX:20663946-20726760 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035597
 protein coding gene ChrX:15690126-15755955 (+)
A/J MGP_AJ_G0035574
 protein coding gene ChrX:15777168-15842305 (+)
AKR/J MGP_AKRJ_G0035507
 protein coding gene ChrX:16325907-16395056 (+)
BALB/cJ MGP_BALBcJ_G0035567
 protein coding gene ChrX:15533916-15610011 (+)
C3H/HeJ MGP_C3HHeJ_G0035285
 protein coding gene ChrX:15912849-15979305 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036103
 protein coding gene ChrX:16105326-16174468 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032967
 protein coding gene ChrX:14039501-14099361 (+)
CAST/EiJ MGP_CASTEiJ_G0034576
 protein coding gene ChrX:15200431-15272031 (+)
CBA/J MGP_CBAJ_G0035254
 protein coding gene ChrX:16845962-16915157 (+)
DBA/2J MGP_DBA2J_G0035406
 protein coding gene ChrX:15577624-15641042 (+)
FVB/NJ MGP_FVBNJ_G0035352
 protein coding gene ChrX:15539497-15551685 (+)
LP/J MGP_LPJ_G0035488
 protein coding gene ChrX:15946932-16011707 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035396
 protein coding gene ChrX:17098738-17174378 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036110
 protein coding gene ChrX:15605978-15678417 (+)
PWK/PhJ MGP_PWKPhJ_G0034277
 protein coding gene ChrX:14764717-14841903 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034117
 protein coding gene ChrX:15657662-15674886 (+)
WSB/EiJ MGP_WSBEiJ_G0034711
 protein coding gene ChrX:15474857-15545054 (+)



Homology
more
  • Human Ortholog
    ARAF, A-Raf proto-oncogene, serine/threonine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARAF, A-Raf proto-oncogene, serine/threonine kinase
  • Synonyms
    A-RAF, ARAF1, PKS2, RAFA1
  • Links
    NCBI Gene ID: 369
    neXtProt AC: NX_P10398
    UniProt: P10398

  • Chr Location
    Xp11.3; chrX:47561205-47571908 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous females or hemizygous males for a null targeted mutation show variable genetic background effects, from preweaning death, wasting, tremors, distended colon and small thymus to normal survival and breeding with mild neurological defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    85
  • cDNA Data
    24
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001127 Ensembl Gene Model | MGI Sequence Detail 62706 C57BL/6J ±  kb
    transcript ENSMUST00000001155 Ensembl | MGI Sequence Detail 2358 Not Applicable  
    polypeptide ENSMUSP00000001155 Ensembl | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000004192 serine/threonine-protein kinase A-Raf
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR020454 Diacylglycerol/phorbol-ester binding
      IPR017441 Protein kinase, ATP binding site
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR003116 Raf-like Ras-binding
      IPR051681 Serine/Threonine Kinases and Pseudokinases
      IPR050167 Serine/threonine-protein kinase
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR029071 Ubiquitin-like domain superfamily
    • GlyGen
      P04627 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 2
      cDNA 27
      Primer pair 2
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1385, MGI:1914126, MGI:2148014
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 11
    • Earliest
      J:8306 Huebner K, et al., Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3934-8
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory