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Avp Gene Detail
Summary
  • Symbol
    Avp
  • Name
    arginine vasopressin
  • Synonyms
    Vp, Vsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:88121
    NCBI Gene: 11998
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130422540-130424474 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.24 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    150 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88121
 protein coding gene Chr2:130422540-130424508 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026509
 protein coding gene Chr2:134046637-134048571 (-)
A/J MGP_AJ_G0026473
 protein coding gene Chr2:128620032-128621966 (-)
AKR/J MGP_AKRJ_G0026448
 protein coding gene Chr2:132329674-132331608 (-)
BALB/cJ MGP_BALBcJ_G0026485
 protein coding gene Chr2:128975051-128976984 (-)
C3H/HeJ MGP_C3HHeJ_G0026228
 protein coding gene Chr2:132760919-132762853 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026930
 protein coding gene Chr2:138187376-138189310 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024307
 protein coding gene Chr2:123364046-123366006 (-)
CAST/EiJ MGP_CASTEiJ_G0025689
 protein coding gene Chr2:133016668-133018601 (-)
CBA/J MGP_CBAJ_G0026208
 protein coding gene Chr2:143295937-143297871 (-)
DBA/2J MGP_DBA2J_G0026342
 protein coding gene Chr2:128006870-128008804 (-)
FVB/NJ MGP_FVBNJ_G0026306
 protein coding gene Chr2:126634534-126636468 (-)
LP/J MGP_LPJ_G0026447
 protein coding gene Chr2:134291833-134293767 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026326
 protein coding gene Chr2:147144975-147146909 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026985
 protein coding gene Chr2:132283979-132285913 (-)
PWK/PhJ MGP_PWKPhJ_G0025425
 protein coding gene Chr2:127563245-127565178 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025227
 protein coding gene Chr2:131407030-131408934 (-)
WSB/EiJ MGP_WSBEiJ_G0025763
 protein coding gene Chr2:133206754-133208688 (-)



Homology
more
  • Human Ortholog
    AVP, arginine vasopressin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AVP, arginine vasopressin
  • Synonyms
    ADH, ARVP, AVP-NPII, AVRP, VP
  • Links
    NCBI Gene ID: 551
    neXtProt AC: NX_P01185
    UniProt: P01185

  • Chr Location
    20p13; chr20:3082556-3084724 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Avp mouse models; 2 with human AVP associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 6 alleles in 5 genetic backgrounds
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a premature stop mutation display postnatal lethality. Heterozygous mice display polyuria, increased water intake, decreased urine osmolality, and hypothalamic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1084
  • Tissues
    211
  • cDNA Data
    18
  • Literature Summary
    65
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037727 Ensembl Gene Model | MGI Sequence Detail 1935 C57BL/6J ±  kb
    transcript ENSMUST00000046001 Ensembl | MGI Sequence Detail 577 Not Applicable  
    polypeptide ENSMUSP00000035551 Ensembl | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004523 vasopressin-neurophysin 2-copeptin
      (term hierarchy)
    • InterPro Domains
      IPR000981 Neurohypophysial hormone
      IPR022423 Neurohypophysial hormone, conserved site
      IPR036387 Neurohypophysial hormone domain superfamily
    • GlyGen
      P35455 1 site, 4 N-linked glycans (1 site)
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 10
      cDNA 19
      Primer pair 3
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1485, MGD-MRK-15404, MGD-MRK-15416
    References
    more
    • Summaries
      All 195
      Developmental Gene Expression 65
      Diseases 2
      Gene Ontology 6
      Phenotypes 61
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:358385 Zuchowski Y, et al., Kidney collecting duct-derived vasopressin is not essential for appropriate concentration or dilution of urine. Am J Physiol Renal Physiol. 2024 Jun 1;326(6):F1091-F1100
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory