Bcl2l1 MGI Mouse Gene Detail - MGI:88139

Symbol

Bcl2l1
Name

BCL2-like 1
Synonyms

bcl-x, BclX, Bcl(X)L, Bcl-XL, Bcl-Xs

Feature Type

protein coding gene
IDs

MGI:88139
NCBI Gene: 12048
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr2:152622588-152673648 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 75.41 cM, cytoband H1
Mapping Data

5 experiments

SNPs within 2kb

894 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88139	protein coding gene	Chr2:152600652-152673648 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026678	protein coding gene	Chr2:157360380-157415302 (-)
A/J	MGP_AJ_G0026644	protein coding gene	Chr2:151075895-151127527 (-)
AKR/J	MGP_AKRJ_G0026614	protein coding gene	Chr2:155479529-155532241 (-)
BALB/cJ	MGP_BALBcJ_G0026653	protein coding gene	Chr2:151385819-151436728 (-)
C3H/HeJ	MGP_C3HHeJ_G0026396	protein coding gene	Chr2:155867676-155918653 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027102	protein coding gene	Chr2:161925370-161980067 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024473	protein coding gene	Chr2:144668185-144719917 (-)
CAST/EiJ	MGP_CASTEiJ_G0025857	protein coding gene	Chr2:156118793-156171743 (-)
CBA/J	MGP_CBAJ_G0026374	protein coding gene	Chr2:167886542-167940199 (-)
DBA/2J	MGP_DBA2J_G0026510	protein coding gene	Chr2:150288525-150340505 (-)
FVB/NJ	MGP_FVBNJ_G0026476	protein coding gene	Chr2:148745789-148796675 (-)
LP/J	MGP_LPJ_G0026614	protein coding gene	Chr2:157518014-157569648 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026497	protein coding gene	Chr2:171965189-172018246 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027158	protein coding gene	Chr2:155382681-155434217 (-)
PWK/PhJ	MGP_PWKPhJ_G0025591	protein coding gene	Chr2:149810805-149863055 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025394	protein coding gene	Chr2:154222423-154277918 (-)
WSB/EiJ	MGP_WSBEiJ_G0025927	protein coding gene	Chr2:156288045-156342148 (-)

Human Ortholog

BCL2L1, BCL2 like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCL2L1, BCL2 like 1
Synonyms

BCL2L, Bcl-X, BCLX, BCL-XL/S, PPP1R52
Links

HGNC:992

NCBI Gene ID: 598

neXtProt AC: NX_Q07817

UniProt: Q07817
Chr Location

20q11.21; chr20:31664452-31723989 (-) GRCh38

MGI Vertebrate Homology

Bcl2l1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BCL2L1
Gene Tree

Bcl2l1

Diseases

7 with human BCL2L1 associations

				Human Disease	Mouse Models
				acute lymphoblastic leukemia IDs acute lymphoblastic leukemia DOID:9952 EFO:0000220 ICD10CM:C91.00 ICD9CM:204.0 NCI:C3167 NCI:C7055 OMIM:247640 OMIM:613065 ORDO:513 UMLS_CUI:C0023449 UMLS_CUI:C1335469
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				chronic myeloid leukemia IDs chronic myeloid leukemia DOID:8552 DOID:8551 DOID:8606 EFO:0000339 ICD9CM:205.1 KEGG:05220 OMIM:608232 ORDO:521 UMLS_CUI:C0023473
				lymphoid leukemia IDs lymphoid leukemia DOID:1037 ICD10CM:C91 ICD9CM:204 ICD9CM:204.2 ICD9CM:204.9 MESH:D007945 NCI:C7539 UMLS_CUI:C0023448
				pancreatic cancer IDs pancreatic cancer DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463
				prostate carcinoma IDs prostate carcinoma DOID:10286 EFO:0001663 KEGG:05215 NCI:C4863 UMLS_CUI:C0600139
				transitional cell carcinoma IDs transitional cell carcinoma DOID:2671 DOID:3995 MESH:D002295 NCI:C2930 NCI:C6783 UMLS_CUI:C0007138 UMLS_CUI:C0334265

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

36 phenotypes from 9 alleles in 10 genetic backgrounds
20 phenotypes from multigenic genotypes
90 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

143
Chemically induced (ENU)

2
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

129
Radiation induced

1
Targeted

8
Transgenic

1
Genomic Mutations

2 involving Bcl2l1
Find Mice (IMSR)

104 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants die at embryonic day 13 with extensive apoptotic cell death, hypomorphic mutants have severe reproductive defects due to abnormal germ cell development. Mice lacking the gamma isoform show immune defects.

less

All GO Annotations

137
GO References

44

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1055
Tissues

165
cDNA Data

120
Literature Summary

72

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bcl2l1

ZFIN bcl2l1

less

All Sequences

93
RefSeq

20
UniProt

8
CCDS

CCDS16899.1

Ensembl

ENSMUSG00000007659 (Evidence)
NCBI Gene

12048

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007659	Ensembl Gene Model \| MGI Sequence Detail	51061	C57BL/6J	± kb
transcript	ENSMUST00000007803	Ensembl \| MGI Sequence Detail	2417	Not Applicable
polypeptide	ENSMUSP00000007803	Ensembl \| MGI Sequence Detail	233	Not Applicable

less

UniProt

8 Sequences
Protein Ontology

PR:000002308 Bcl-2-like protein 1

(term hierarchy)
PDB

1PQ0, 1PQ1, 2BZW, 3IHC, 3IHD, 3IHE, 3IHF, 3IIG, 3IIH, 3ILB, 3ILC, 4YJ4, 4YK9, 5C3G, 7WJH, 7Y99
InterPro Domains

IPR004725 Apoptosis regulator, Bcl-2/ BclX

IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site

IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site

IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site

IPR020731 Apoptosis regulator, Bcl-2, BH4 motif, conserved site

IPR003093 Apoptosis regulator, Bcl-2 protein, BH4

IPR013279 Apoptosis regulator, Bcl-X

IPR046371 Bcl-2, Bcl-2 homology region 1-3

IPR026298 Bcl-2 family

IPR002475 Bcl2-like

IPR036834 Bcl-2-like superfamily

less

All nucleic 142

Genomic 3

cDNA 120

Primer pair 14

Other 5

Microarray probesets 7

less

MGD-MRK-1527

Summaries

All 338

Developmental Gene Expression 72

Diseases 1

Gene Ontology 44

Phenotypes 90
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:340804 Nakamura M, et al., Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice. Nat Commun. 2023 Sep 19;14(1):5805

TSS for Bcl2l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26873	Chr2:152673585-152673655 (-)	28 bp
Tssr26872	Chr2:152673163-152673246 (-)	443 bp
Tssr26871	Chr2:152672628-152672648 (-)	1,010 bp
Tssr26870	Chr2:152672535-152672600 (-)	1,080 bp
Tssr26869	Chr2:152672478-152672506 (-)	1,156 bp
Tssr26868	Chr2:152672400-152672415 (-)	1,240 bp
Tssr26867	Chr2:152672330-152672337 (-)	1,314 bp
Tssr26866	Chr2:152672186-152672199 (-)	1,455 bp
Tssr26865	Chr2:152672138-152672176 (-)	1,491 bp
Tssr26864	Chr2:152668093-152668101 (-)	5,551 bp
Tssr26863	Chr2:152667674-152667682 (-)	5,970 bp
Tssr26862	Chr2:152656890-152656895 (-)	16,755 bp
Tssr26861	Chr2:152647995-152648020 (-)	25,640 bp
Tssr26860	Chr2:152645126-152645135 (-)	28,517 bp
Tssr26859	Chr2:152634495-152634505 (-)	39,148 bp
Tssr26858	Chr2:152629543-152629565 (-)	44,094 bp
Tssr26857	Chr2:152623861-152623886 (-)	49,774 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24