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Bcl2l1 Gene Detail
Summary
  • Symbol
    Bcl2l1
  • Name
    BCL2-like 1
  • Synonyms
    bcl-x, BclX, Bcl(X)L, Bcl-XL, Bcl-Xs
  • Feature Type
    protein coding gene
  • IDs
    MGI:88139
    NCBI Gene: 12048
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152622588-152673648 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.41 cM, cytoband H1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    894 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88139
 protein coding gene Chr2:152600652-152673648 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026678
 protein coding gene Chr2:157360380-157415302 (-)
A/J MGP_AJ_G0026644
 protein coding gene Chr2:151075895-151127527 (-)
AKR/J MGP_AKRJ_G0026614
 protein coding gene Chr2:155479529-155532241 (-)
BALB/cJ MGP_BALBcJ_G0026653
 protein coding gene Chr2:151385819-151436728 (-)
C3H/HeJ MGP_C3HHeJ_G0026396
 protein coding gene Chr2:155867676-155918653 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027102
 protein coding gene Chr2:161925370-161980067 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024473
 protein coding gene Chr2:144668185-144719917 (-)
CAST/EiJ MGP_CASTEiJ_G0025857
 protein coding gene Chr2:156118793-156171743 (-)
CBA/J MGP_CBAJ_G0026374
 protein coding gene Chr2:167886542-167940199 (-)
DBA/2J MGP_DBA2J_G0026510
 protein coding gene Chr2:150288525-150340505 (-)
FVB/NJ MGP_FVBNJ_G0026476
 protein coding gene Chr2:148745789-148796675 (-)
LP/J MGP_LPJ_G0026614
 protein coding gene Chr2:157518014-157569648 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026497
 protein coding gene Chr2:171965189-172018246 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027158
 protein coding gene Chr2:155382681-155434217 (-)
PWK/PhJ MGP_PWKPhJ_G0025591
 protein coding gene Chr2:149810805-149863055 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025394
 protein coding gene Chr2:154222423-154277918 (-)
WSB/EiJ MGP_WSBEiJ_G0025927
 protein coding gene Chr2:156288045-156342148 (-)



Homology
more
  • Human Ortholog
    BCL2L1, BCL2 like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL2L1, BCL2 like 1
  • Synonyms
    BCL2L, Bcl-X, BCLX, BCL-XL/S, PPP1R52
  • Links
    NCBI Gene ID: 598
    neXtProt AC: NX_Q07817
    UniProt: Q07817

  • Chr Location
    20q11.21; chr20:31664452-31723989 (-)  GRCh38
Human Diseases
more
  • Diseases
    7 with human BCL2L1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 9 alleles in 10 genetic backgrounds
    20 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die at embryonic day 13 with extensive apoptotic cell death, hypomorphic mutants have severe reproductive defects due to abnormal germ cell development. Mice lacking the gamma isoform show immune defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    137
  • GO References
    44
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1055
  • Tissues
    165
  • cDNA Data
    120
  • Literature Summary
    72
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007659 Ensembl Gene Model | MGI Sequence Detail 51061 C57BL/6J ±  kb
    transcript ENSMUST00000007803 Ensembl | MGI Sequence Detail 2417 Not Applicable  
    polypeptide ENSMUSP00000007803 Ensembl | MGI Sequence Detail 233 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      Genomic 3
      cDNA 120
      Primer pair 14
      Other 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1527
    References
    more
    • Summaries
      All 340
      Developmental Gene Expression 72
      Diseases 1
      Gene Ontology 44
      Phenotypes 91
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:358134 Soma S, et al., O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. Stem Cells. 2024 Jan 13;42(1):55-63
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory