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Bglap Gene Detail
Summary
  • Symbol
    Bglap
  • Name
    bone gamma carboxyglutamate protein
  • Synonyms
    Bglap1, bone Gla protein, mOC-A, OC, OG1, osteocalcin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88156
    NCBI Gene: 12096
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88290808-88291771 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.82 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    8
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88156
 protein coding gene Chr3:88290802-88291773 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027394
 protein coding gene Chr3:88539980-88541000 (-)
A/J MGP_AJ_G0027358
 protein coding gene Chr3:85546305-85547263 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0027367
 protein coding gene Chr3:85628310-85629074 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0027209
 protein coding gene Chr3:101154600-101155614 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027872
 protein coding gene Chr3:87386732-87387671 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026108
 protein coding gene Chr3:86576471-86577333 (-)
WSB/EiJ MGP_WSBEiJ_G0026636
 protein coding gene Chr3:87754534-87755396 (-)



Homology
more
  • Human Ortholog
    BGLAP, bone gamma-carboxyglutamate protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BGLAP, bone gamma-carboxyglutamate protein
  • Synonyms
    BGP, OC, OCN
  • Links
    NCBI Gene ID: 632
    neXtProt AC: NX_P02818
    UniProt: P02818

  • Chr Location
    1q22; chr1:156242184-156243317 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human BGLAP associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 2 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele of both Bglap1 and Bglap2 exhibit decreased circulating insulin, impaired glucose tolerance, increased adipose tissue, increased bone density, and decreased male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    950
  • Tissues
    102
  • cDNA Data
    9
  • Literature Summary
    224
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074483 Ensembl Gene Model | MGI Sequence Detail 964 C57BL/6J ±  kb
    transcript ENSMUST00000076048 Ensembl | MGI Sequence Detail 440 Not Applicable  
    polypeptide ENSMUSP00000075425 Ensembl | MGI Sequence Detail 95 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR039176 Osteocalcin
      IPR002384 Osteocalcin/matrix Gla protein
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 3
      cDNA 15
      Primer pair 17
      Other 24

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1550, MGD-MRK-1552
    References
    more
    • Summaries
      All 339
      Developmental Gene Expression 224
      Diseases 1
      Gene Ontology 16
      Phenotypes 37
    • Earliest
      J:8426 Celeste AJ, et al., Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J. 1986 Aug;5(8):1885-90
    • Latest
      J:353622 Dinesh NEH, et al., Fibronectin Isoforms Promote Postnatal Skeletal Development. Matrix Biol. 2024 Aug 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory