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Blvra Gene Detail
Summary
  • Symbol
    Blvra
  • Name
    biliverdin reductase A
  • Synonyms
    0610006A11Rik, 2500001N03Rik, Blvr
  • Feature Type
    protein coding gene
  • IDs
    MGI:88170
    NCBI Gene: 109778
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:126912585-126939004 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.76 cM, cytoband F3
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    775 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88170
 protein coding gene Chr2:126912549-126939004 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026448
 protein coding gene Chr2:130322802-130349810 (+)
A/J MGP_AJ_G0026412
 protein coding gene Chr2:125049186-125076451 (+)
AKR/J MGP_AKRJ_G0026387
 protein coding gene Chr2:128614519-128641196 (+)
BALB/cJ MGP_BALBcJ_G0026424
 protein coding gene Chr2:125323922-125350170 (+)
C3H/HeJ MGP_C3HHeJ_G0026167
 protein coding gene Chr2:129129197-129156653 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026869
 protein coding gene Chr2:134434018-134459704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024246
 protein coding gene Chr2:119752025-119775993 (+)
CAST/EiJ MGP_CASTEiJ_G0025628
 protein coding gene Chr2:129339255-129369684 (+)
CBA/J MGP_CBAJ_G0026147
 protein coding gene Chr2:139395557-139425743 (+)
DBA/2J MGP_DBA2J_G0026281
 protein coding gene Chr2:124447248-124473119 (+)
FVB/NJ MGP_FVBNJ_G0026245
 protein coding gene Chr2:123110700-123136380 (+)
LP/J MGP_LPJ_G0026386
 protein coding gene Chr2:130575201-130601377 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026265
 protein coding gene Chr2:143446501-143475315 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026924
 protein coding gene Chr2:128645101-128673541 (+)
PWK/PhJ MGP_PWKPhJ_G0025364
 protein coding gene Chr2:123993774-124021877 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025166
 protein coding gene Chr2:127710076-127731784 (+)
WSB/EiJ MGP_WSBEiJ_G0025702
 protein coding gene Chr2:129535739-129563470 (+)



Homology
more
  • Human Ortholog
    BLVRA, biliverdin reductase A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BLVRA, biliverdin reductase A
  • Synonyms
    BLVR, BVR, BVRA, BVRalpha
  • Links
    NCBI Gene ID: 644
    neXtProt AC: NX_P53004
    UniProt: P53004

  • Chr Location
    7p13; chr7:43758122-43807342 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit high mean erythrocyte cell number, increased mean corpuscular hemoglobin concentration, decreased mean corpuscular volume, decreased mean corpuscular hemoglobin, green gall bladder, yellow bile, bile composed of biliverdin rather than bilirubin, and increased endogenous oxidative stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    4
  • cDNA Data
    42
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001999 Ensembl Gene Model | MGI Sequence Detail 26420 C57BL/6J ±  kb
    transcript ENSMUST00000002064 Ensembl | MGI Sequence Detail 1160 Not Applicable  
    polypeptide ENSMUSP00000002064 Ensembl | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 43

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1581, MGI:1915580, MGI:1917355
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory