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Bmp1 Gene Detail
Summary
  • Symbol
    Bmp1
  • Name
    bone morphogenetic protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88176
    NCBI Gene: 12153
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70711998-70757674 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1116 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88176
 protein coding gene Chr14:70711998-70758280 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021539
 protein coding gene Chr14:65126663-65173840 (-)
A/J MGP_AJ_G0021498
 protein coding gene Chr14:63743044-63789582 (-)
AKR/J MGP_AKRJ_G0021474
 protein coding gene Chr14:65654193-65701521 (-)
BALB/cJ MGP_BALBcJ_G0021504
 protein coding gene Chr14:63505978-63552547 (-)
C3H/HeJ MGP_C3HHeJ_G0021281
 protein coding gene Chr14:65370041-65416192 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021943
 protein coding gene Chr14:68038101-68087367 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019483
 protein coding gene Chr14:61578185-61627136 (-)
CAST/EiJ MGP_CASTEiJ_G0020798
 protein coding gene Chr14:61964465-62010521 (-)
CBA/J MGP_CBAJ_G0021248
 protein coding gene Chr14:70178885-70227192 (-)
DBA/2J MGP_DBA2J_G0021371
 protein coding gene Chr14:63127103-63173241 (-)
FVB/NJ MGP_FVBNJ_G0021350
 protein coding gene Chr14:62556865-62603399 (-)
LP/J MGP_LPJ_G0021442
 protein coding gene Chr14:66368501-66416257 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021379
 protein coding gene Chr14:69067678-69115373 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021967
 protein coding gene Chr14:64917040-64964448 (-)
PWK/PhJ MGP_PWKPhJ_G0020542
 protein coding gene Chr14:59894034-59940476 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020375
 protein coding gene Chr14:60843068-60891010 (-)
WSB/EiJ MGP_WSBEiJ_G0020851
 protein coding gene Chr14:65226748-65276567 (-)



Homology
more
  • Human Ortholog
    BMP1, bone morphogenetic protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP1, bone morphogenetic protein 1
  • Synonyms
    OI13, PCOLC, PCP, PCP2, TLD
  • Links
    NCBI Gene ID: 649
    neXtProt AC: NX_P13497
    UniProt: P13497

  • Chr Location
    8p21.3; chr8:22165140-22212326 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BMP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    49 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutant embryos have reduced ossification of the skull, persistent herniation of the gut, abnormal collagen fibrils in the amnion, and die at birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    107
  • cDNA Data
    149
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022098 Ensembl Gene Model | MGI Sequence Detail 45677 C57BL/6J ±  kb
    transcript ENSMUST00000022693 Ensembl | MGI Sequence Detail 3684 Not Applicable  
    polypeptide ENSMUSP00000022693 Ensembl | MGI Sequence Detail 991 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      Genomic 1
      cDNA 151
      Primer pair 3
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1592
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 30
      Diseases 1
      Gene Ontology 14
      Phenotypes 21
    • Earliest
      J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
    • Latest
      J:348273 Wan S, et al., Activated hepatic stellate cell-derived Bmp-1 induces liver fibrosis via mediating hepatocyte epithelial-mesenchymal transition. Cell Death Dis. 2024 Jan 12;15(1):41
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory