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Bmp6 Gene Detail
Summary
  • Symbol
    Bmp6
  • Name
    bone morphogenetic protein 6
  • Synonyms
    D13Wsu115e, Vgr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88182
    NCBI Gene: 12161
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr13:38529098-38684283 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 18.15 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3999 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88182
 protein coding gene Chr13:38529083-38684283 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020472
 protein coding gene Chr13:36681491-36852595 (+)
A/J MGP_AJ_G0020426
 protein coding gene Chr13:35522665-35674997 (+)
AKR/J MGP_AKRJ_G0020404
 protein coding gene Chr13:36459415-36623112 (+)
BALB/cJ MGP_BALBcJ_G0020422
 protein coding gene Chr13:35622799-35776590 (+)
C3H/HeJ MGP_C3HHeJ_G0020221
 protein coding gene Chr13:36295721-36452137 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020855
 protein coding gene Chr13:37894324-38052013 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018442
 protein coding gene Chr13:33702743-33856475 (+)
CAST/EiJ MGP_CASTEiJ_G0019736
 protein coding gene Chr13:36071012-36229204 (+)
CBA/J MGP_CBAJ_G0020182
 protein coding gene Chr13:39485053-39653689 (+)
DBA/2J MGP_DBA2J_G0020304
 protein coding gene Chr13:35039624-35196627 (+)
FVB/NJ MGP_FVBNJ_G0020283
 protein coding gene Chr13:34571056-34725771 (+)
LP/J MGP_LPJ_G0020379
 protein coding gene Chr13:36934147-37097708 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020313
 protein coding gene Chr13:39584167-39745669 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020898
 protein coding gene Chr13:36035639-36195143 (+)
PWK/PhJ MGP_PWKPhJ_G0019491
 protein coding gene Chr13:35166269-35321869 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019322
 protein coding gene Chr13:34703350-34868206 (+)
WSB/EiJ MGP_WSBEiJ_G0019798
 protein coding gene Chr13:36382884-36544182 (+)



Homology
more
  • Human Ortholog
    BMP6, bone morphogenetic protein 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP6, bone morphogenetic protein 6
  • Synonyms
    IO, VGR, VGR1
  • Links
    NCBI Gene ID: 654
    neXtProt AC: NX_P22004
    UniProt: P22004

  • Chr Location
    6p24.3; chr6:7726099-7881728 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
One homozygous null mutant showed delayed ossification in the developing sternum while females of a second null mutant were smaller than normal in size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1182
  • Tissues
    302
  • cDNA Data
    18
  • Literature Summary
    107
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12161 NCBI Gene Model | MGI Sequence Detail 155186 C57BL/6J ±  kb
    transcript NM_007556 RefSeq | MGI Sequence Detail 3583 ZRU/MplStud  
    polypeptide P20722 UniProt | EBI | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 1
      cDNA 22
      Primer pair 11
      Other 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15388, MGD-MRK-15390, MGD-MRK-1604, MGD-MRK-34025, MGI:106333
    References
    more
    • Summaries
      All 218
      Developmental Gene Expression 107
      Gene Ontology 21
      Phenotypes 33
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory