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Bsg Gene Detail
Summary
  • Symbol
    Bsg
  • Name
    basigin
  • Synonyms
    5A11/Basigin, CD147, EMMPRIN, gp 42, HT-7, neurothelin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88208
    NCBI Gene: 12215
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr10:79540325-79547803 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88208
 protein coding gene Chr10:79540192-79547813 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017454
 protein coding gene Chr10:80246606-80254083 (+)
A/J MGP_AJ_G0017432
 protein coding gene Chr10:77457129-77464634 (+)
AKR/J MGP_AKRJ_G0017393
 protein coding gene Chr10:79561521-79569002 (+)
BALB/cJ MGP_BALBcJ_G0017394
 protein coding gene Chr10:77683472-77690990 (+)
C3H/HeJ MGP_C3HHeJ_G0017217
 protein coding gene Chr10:79671442-79678956 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017848
 protein coding gene Chr10:83021517-83028994 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015536
 protein coding gene Chr10:73683513-73691111 (+)
CAST/EiJ MGP_CASTEiJ_G0016784
 protein coding gene Chr10:79844640-79852106 (+)
CBA/J MGP_CBAJ_G0017189
 protein coding gene Chr10:86243288-86250765 (+)
DBA/2J MGP_DBA2J_G0017295
 protein coding gene Chr10:76673110-76680587 (+)
FVB/NJ MGP_FVBNJ_G0017289
 protein coding gene Chr10:75834968-75842445 (+)
LP/J MGP_LPJ_G0017366
 protein coding gene Chr10:80726067-80733544 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017315
 protein coding gene Chr10:88221533-88229038 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017889
 protein coding gene Chr10:79540324-79547801 (+)
PWK/PhJ MGP_PWKPhJ_G0016565
 protein coding gene Chr10:76530330-76537936 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016354
 protein coding gene Chr10:78514153-78521629 (+)
WSB/EiJ MGP_WSBEiJ_G0016844
 protein coding gene Chr10:79572635-79580208 (+)



Homology
more
  • Human Ortholog
    BSG, basigin (Ok blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BSG, basigin (Ok blood group)
  • Synonyms
    5F7, CD147, EMMPRIN, EMPRIN, HAb18G, OK, TCSF
  • Links
    NCBI Gene ID: 682
    neXtProt AC: NX_P35613
    UniProt: P35613

  • Chr Location
    19p13.3; chr19:571277-583494 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 3 alleles in 5 genetic backgrounds
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous null mutants die around the time of implantation. Half of the survivors die prior to 1 month of age from interstitial pneumonia. The remaining mice are small, sterile, have retinal abnormalities, and perform poorly in behavioral tests.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1206
  • Tissues
    289
  • cDNA Data
    495
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023175 Ensembl Gene Model | MGI Sequence Detail 7479 C57BL/6J ±  kb
    transcript ENSMUST00000067036 Ensembl | MGI Sequence Detail 1526 Not Applicable  
    polypeptide ENSMUSP00000070751 Ensembl | MGI Sequence Detail 389 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 510
      Genomic 3
      cDNA 495
      Primer pair 9
      Other 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1674, MGI:2143523, MGI:2143580
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 17
      Gene Ontology 15
      Phenotypes 51
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345100 Talvi S, et al., Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice. iScience. 2024 Feb 16;27(2):108914
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory